Ma'edamines E and F, rare bromotyrosine alkaloids possessing a 1,2,3,5-tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp.
Ma'edamines E and F, rare bromotyrosine alkaloids possessing a 1,2,3,5-tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp.
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Maedamines E 和 F 是稀有的溴酪氨酸生物碱，具有来自冲绳海洋海绵 Suberea sp 的 1,2,3,5-四取代吡啶鎓部分。
DOI：
10.1016/j.tetlet.2022.153985
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发表时间：
2022
影响因子：
1.8
通讯作者：
Kubota Takaaki
中科院分区：
文献类型：
--
作者：
Kurimoto Shin-ichiro;Okamoto Ayano;Seino Satsuki;Fromont Jane;Kobayashi Jun'ichi;Kubota Takaaki
从冲绳海绵Suberea sp.中分离得到两个新的溴代酪氨酸生物碱，即马依达明E（1）和F（2），并通过光谱（UV、IR、NMR）和质谱（MS）数据分析确定了它们的结构。马伊达明E（1）和F（2）是具有N-烷基-3，5-二乙基-2-丙基吡啶鎓部分的天然产物的第二和第三实例。马伊达明F（2）是第一个同时具有吡啶鎓和季铵部分的溴酪氨酸生物碱。苦参碱E（1）和F（2）对小鼠白血病细胞L1210有一定的体外细胞毒作用。
Two new bromotyrosine alkaloids, ma'edamines E (1) and F (2), were isolated from an Okinawan marine sponge Suberea sp., and their structures were elucidated by the analyses of spectroscopic (UV, IR, and NMR) and spectrometric (MS) data. Ma'edamines E (1) and F (2) are the second and third examples of natural products possessing an N-alkyl-3, 5-diethyl-2-propylpyridinium moiety. Ma'edamine F (2) is the first bromotyrosine alkaloid having both pyridinium and quaternary ammonium moieties. Ma'edamines E (1) and F (2) showed moderate cytotoxicity against L1210 murine leukemia cells in vitro.