Severe orthostatic hypotension associated with lesions of the area postraema in neuromyelitis optica spectrum disorder.
Severe orthostatic hypotension associated with lesions of the area postraema in neuromyelitis optica spectrum disorder.
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DOI：
10.1016/j.ensci.2021.100335
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Kamitsukasa I
中科院分区：
文献类型：
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作者：
Sawai S;Mori M;Makino T;Nakano Y;Kuwabara S;Kamitsukasa I
呃逆、恶心和呕吐是视神经肌萎缩症谱系障碍（NMOSD）的临床表现，与延髓被盖后区病变有关。在此，我们描述一位74岁男性NMOSD患者，因严重直立性低血压（OH）伴打嗝、恶心和呕吐症状而出现反复晕厥。脑磁共振成像显示脑出血后区的病变，它可能是导致OH症状的原因。考虑到大量的相关报道，我们怀疑OH在NMOSD患者中的患病率被低估。OH可能会转变为更严重的疾病，因此应在所有NMOSD患者中仔细评估，特别是当有血肿后区病变时。视神经肌病谱系障碍常累及视后区。一位视神经肌萎缩症患者出现直立性低血压。体位性低血压的发生可能与脑干后区的病变有关。
Hiccups, nausea and vomiting are known as the clinical manifestations of neuromyelitis optica spectrum disorder (NMOSD) linked to lesions of the area postraema in the medullary tegmentum. Here, we describe a 74-year-old male patient with NMOSD who presented with recurrent syncope due to severe orthostatic hypotension (OH) following symptoms of hiccups, nausea and vomiting. Brain magnetic resonance imaging revealed the lesion of the area postraema and it could be responsible for the symptom of OH. Considering the numerous related reports, we suspect that the prevalence of OH is underreported in the patients with NMOSD. OH may transition into more serious conditions, so it should be evaluated carefully in all patients with NMOSD, particularly when there is a lesion of the area postraema. The area postraema is frequently affected in Neuromyelitis optica spectrum disorder. A Neuromyelitis optica spectrum disorder patient presented orthostatic hypotension. The lesion of the area postraema could be responsible for orthostatic hypotension.