Pre-term labour in cases with high maternal testosterone levels
Pre-term labour in cases with high maternal testosterone levels
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DOI：
10.1080/01443610601113979
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发表时间：
2007-02-01
影响因子：
1.3
通讯作者：
Ohno, T.
中科院分区：
文献类型：
--
作者：
Furui, T.;Imai, A.;Ohno, T.
尽管根据各种临床方案进行了彻底的调查，但在约50%的早产中，潜在原因仍未得到解释。内分泌因素，如雄激素浓度升高、高催乳素血症和黄体期缺陷，被认为在自然分娩的开始中起重要作用，特别是在那些在中期或早期妊娠结束，导致极低出生体重新生儿的妊娠中(Bibby和Stewart 2004)。灵长类动物的自然分娩以胎儿肾上腺合成C19雄激素为特征，而C19雄激素又被胎盘芳香化为雌激素(Bibby和Stewart 2004)。外源性雄烯二酮输注导致怀孕猴子早产(Mecenas等人。1996年)。Gravett等人(2000)提出了感染诱导的早产环境中胎儿雄激素产生被激活的证据，尽管仍然存在许多重要问题。我们报告四个与高睾酮水平相关的早产病例。与早产有关的高睾酮水平在四个孕妇中出现，这是导致早产的一个看似合理的原因。
Despite thorough investigation according to various clinical protocols, the underlying cause remains unexplained in about 50% of pre-term deliveries. The role played by endocrinological factors such as increasing androgen concentration, hyperprolactinaemia and luteal phase defect are thought to be important in the onset of spontaneous parturition, especially among those pregnancies that end in the second-or early third-trimester, resulting in very-lowbirth-weight neonates (Bibby and Stewart 2004). Spontaneous parturition in primates is characterised by fetal adrenal synthesis of c19 androgens, which, in turn, are aromatised by the placenta into oestrogens (Bibby and Stewart 2004). Exogenous androstenedione infusion produces premature delivery in pregnant monkeys (Mecenas et al. 1996). Gravett et al.(2000) presented evidence for activation of the fetal androgen production in the setting of infection-induced pre-term labour, although many important questions remain. We present four cases with high testosterone level-associated pre-term labour. High testosterone levels associated with pre-term labour occurred in four pregnancies, providing one plausible cause of premature parturition.