Effects of renal failure on blood levels of cimetidine.
Effects of renal failure on blood levels of cimetidine.
复制标题
肾功能衰竭对西咪替丁血液浓度的影响。
DOI：
10.1016/0016-5085(78)90786-2
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发表时间：
1978
期刊：
影响因子：
29.4
通讯作者：
S. Silvis
中科院分区：
文献类型：
--
作者：
K. Ma;D. C. Brown;D. Masler;S. Silvis
静脉注射 300 mg 西咪替丁后，采集连续血样用于测定药物水平。对 16 名患有不同程度肾衰竭的患者进行了研究。与正常对照相比，肾功能不全患者的药物半衰期延长（P<0.001）。半衰期和肌酐清除率之间存在显着的反比关系（r=0.69；P<0.01）。对 12 名患者进行了血液透析的效果研究。发现西咪替丁是可透析的。这通过透析过程中药物半衰期的缩短和透析率的测量来证明。这表明肾功能不全患者和血液透析患者的剂量方案应进行修改。患者对单次静脉注射西咪替丁的耐受性良好。一名患者出现荨麻疹性皮疹，据信本质上是过敏。 5 名中度肾衰竭患者的血尿素氮和血清肌酐浓度出现短暂、轻度（但显着）升高。
Serial blood samples for determination of drug levels were obtained after intravenous administration of 300 mg of cimetidine. Sixteen patients with varying degrees of renal failure were studied. There was a prolongation of drug half-life in patients with renal insufficiency compared with that in normal controls (P< 0.001). A significant inverse relationship between the half-life and the creatinine clearance was noted (r= 0.69;P< 0.01). The effect of hemodialysis was studied in 12 patients. Cimetidine was found to be dialyzable. This was demonstrated both by a shortening of the half-life of the drug during dialysis and by measurement of dialysance. This suggests that the dose schedule should be modified for patients with renal insufficiency and for those on hemodialysis. A single intravenous dose of cimetidine was well tolerated by the patients. One patient developed an urticarial skin rash, believed to be allergic in nature. There was a transient, mild (but significant) rise in blood urea nitrogen and serum creatinine concentration in 5 patients with moderate renal failure.