Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander
Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander
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DOI：
10.1371/journal.pone.0017780
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发表时间：
2011-03-29
期刊：
影响因子：
3.7
通讯作者：
Erdman, Dean
中科院分区：
文献类型：
--
作者：
Fry, Alicia M.;Lu, Xiaoyan;Erdman, Dean
背景：我们描述了在泰国SaKaeo省发现的人鼻病毒（HRV）。方法：2003年9月1日至2005年8月31日，对急性下呼吸道疾病住院患者和无发热及呼吸道症状的门诊对照进行hrv聚合酶链反应和分子型选择hrv检测。我们比较了住院患者和对照组的HRV检测，并估计了入组调整后的发病率。结果：1919例住院患者中有315例（16%）检测到hrv， 280例对照中有27例（9.6%）检测到hrv。儿童HRV检出率最高（住院：65岁：9%；对照组：65岁：2.8%）。入组调整后住院HRV检出率在65岁人群中最高（71）。所有三种HRV均被确定，HRV- a是大多数年龄组（包括19岁的儿童）中最常见的一种，儿童更容易检测到HRV（比值比[OR]: 4.8, 95%可信区间[CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3），住院儿童更容易检测到HRV- a （OR 1.7, CI: 0.8, 3.5）或HRV- c （OR 2.7, CI: 1.2, 5.9）。结论：住院儿童和老年人HRV检出率较高，但无症状儿童HRV检出率也较高。HRV（所有物种）、HRV- a和HRV- c检测与住院疾病存在流行病学相关性。在泰国，对HRV有效的治疗或预防方式可以减少因HRV而住院的人数。
Background: We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.Methods: From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.Results: HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: = 65 years: 9%; controls: = 65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged = 65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged = 19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.Conclusions: HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.