Trp channels and itch.
Trp channels and itch.
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DOI：
10.1007/s00281-015-0530-4
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发表时间：
2016-05
影响因子：
9
通讯作者：
Dong X
中科院分区：
文献类型：
--
作者：
Sun S;Dong X
痒是一种与抓挠反射有关的独特感觉。虽然抓挠反射在日常生活中通过去除刺激物起保护作用，但慢性瘙痒仍然是临床挑战。尽管迫切的临床需求，瘙痒已收到相对较少的研究关注，其机制仍然知之甚少，直到最近。本综述的目的是总结我们目前对急性和慢性瘙痒机制的理解，以及与瞬时受体电位（Trp）通道相关的原发性瘙痒人群的分类，该通道在多种躯体感觉中起着关键作用。Trp通道在不同瘙痒信号传导途径中的会聚参与表明Trp通道可以作为慢性瘙痒治疗的有希望的靶点。
Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently. The goal of the present review is to summarize our current understanding of the mechanisms of acute as well as chronic itch and classifications of the primary itch populations in relationship to transient receptor potential (Trp) channels, which play pivotal roles in multiple somatosensations. The convergent involvement of Trp channels in diverse itch signaling pathways suggests that Trp channels may serve as promising targets for chronic itch treatments.