Preparation and characterization of calcium phosphate bone cement with rapidly-generated tubular macroporous structure by incorporation of polysaccharide-based microstrips
Preparation and characterization of calcium phosphate bone cement with rapidly-generated tubular macroporous structure by incorporation of polysaccharide-based microstrips
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DOI：
10.1016/j.ceramint.2016.11.199
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发表时间：
2017-03
影响因子：
5.2
通讯作者：
Kannaporn Pooput;N. Monmaturapoj;Jitlada Sansatsadeekul;S. Channasanon;A. Srion
中科院分区：
文献类型：
--
作者：
Kannaporn Pooput;N. Monmaturapoj;Jitlada Sansatsadeekul;S. Channasanon;A. Srion
磷酸钙骨水泥（CPCs）因其生物相容性、骨导电性和原位固化能力而被广泛应用于骨缺损修复。它们很难降解，因此限制了它们在组织工程中的应用。提高CPC降解速度的一种可能策略是在CPC中添加孔隙剂以形成大孔，从而增强骨水泥的吸收，从而被新骨所取代。由于气孔原呈球形，限制了新骨形成的范围，形成的大孔一般不连通。本研究的目的是通过掺入快溶麦芽糊精微带（MDMS）制备具有管状大孔结构的聚丙烯腈（CPCs），并研究其固化时间、力学性能、微观结构和可降解性等性能。结果表明，MDMS包埋复合材料在生理条件下的模拟体液中浸泡1 d后，MDMS迅速降解（70%以上），在CPCs中形成管状大孔。MDMS在1周内完成崩解。MDMS含量低于30%的CPCs的最终凝固时间与不含MDMS的CPCs相同。随着MDMS的分解，CPC复合材料的抗压强度平均值降低。孔隙度和孔隙连通性随MDMS含量的增加而增加。此外，mdms包埋的cpc具有良好的细胞粘附性，是一种可能的骨移植替代品。
Calcium phosphate cements (CPCs) have been extensively used as bone graft substitutes for the repair of bone defect due to its biocompatibility, osteoconductivity and in-situ setting capability. They poorly degrade thus limiting their use in tissue engineering application. A possible strategy to improve the speed of CPC degradation is to add porogen to CPC to create macropores that can enhance cement resorption and can consequently be replaced by new bone. The as-generated macropores are generally not connected because of spherical shape of the porogens which can limit the extent of newly formed bone. The aim of this study was to fabricate CPCs having tubular macroporous structure by incorporating fast-dissolving maltodextrin microstrips (MDMS) and explore their properties such as setting time, mechanical property, microstructure and degradability of the cements. The results showed that after immersing MDMS-embedded composites in simulated body fluid under physiological condition for 1 d MDMS rapidly disintegrated (more than 70%), generating tubular macropores in CPCs. The disintegration of MDMS completed in 1 week. CPCs containing MDMS lower than 30% by weight had the same final setting time as those without MDMS. The average values of compressive strength of the CPC composites decreased with the disintegration of MDMS. % Porosity and pore interconnectivity increased with increasing MDMS content. In addition, MDMS-embedded CPCs were cell friendly with excellent cell adhesion, indicating a possible candidate as bone graft substitutes.