Biocompatible AIE material from natural resources: Chitosan and its multifunctional applications
Biocompatible AIE material from natural resources: Chitosan and its multifunctional applications
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来自自然资源的生物相容性AIE材料：壳聚糖及其多功能应用
DOI：
10.1016/j.carbpol.2019.115338
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发表时间：
2020-01-01
影响因子：
11.2
通讯作者：
Wang, Caiqi
中科院分区：
文献类型：
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作者：
Dong, Zhenzhen;Cui, Hanrui;Wang, Caiqi
因此，迫切需要具有良好的水溶性、生物相容性、可降解性和大规模生产的新型AIE材料。本研究发现，壳聚糖作为一种天然多糖，在固态和溶液状态下均具有荧光发射，并具有AIE效应，探索了壳聚糖的多功能应用。壳聚糖可以在不同的激发波长下发射从蓝色到红色的各种颜色，在细胞水平上具有优异的荧光成像能力。利用壳聚糖的阳离子和抗菌特性，可以通过AIE效应实现细菌的定量。同时，它可用作荧光探针，通过点亮细菌进行多通道细菌成像。壳聚糖溶液对Fe ~（3+）具有灵敏的猝灭响应，可作为检测Fe ~（3+）浓度的生物传感器。这些有趣的结果表明，壳聚糖作为一类新的AIE材料具有广阔的应用前景。
New sources of AIE materials with good water solubility, biocompatibility, degradability, and mass production are urgently needed. Here, we found that chitosan, a very abundant polysaccharide in nature, has fluorescence emission in both solid and solution states with AIE effect, and explored its multifunctional applications. Chitosan can emit a variety of colors from blue to red at different excitation wavelengths with excellent multicolor imaging capabilities at the cellular level. Utilizing the cationic and antibacterial properties of chitosan, the quantification of bacteria can be achieved through the AIE effect. Concurrently, it can be used as fluorescent probes for multi-channel bacterial imaging via lighting-up bacteria. Furthermore, the chitosan solution exhibits a sensitive quenching response to Fe3+, which can be used as a biosensor for detecting the concentration of Fe3+. These interesting results indicate that chitosan will have broad application prospects as a new class of AIE material.