Co-Existence of BKV Nephropathy and Disseminated Tuberculosis in Transplant Recipient
Co-Existence of BKV Nephropathy and Disseminated Tuberculosis in Transplant Recipient
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DOI：
10.4103/1319-2442.139936
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发表时间：
2014-09-01
影响因子：
0.5
通讯作者：
Al-Hwiesh, Abdullah
中科院分区：
文献类型：
--
作者：
Al-Warthan, Sarah;Al-Hwiesh, Abdullah
肾移植受者的结核病（TB）存在重要的诊断困难，因为肺外受累的发生率较高，尽管疾病处于活动状态且表现不典型，特别是潜伏形式的重新激活，但痰涂片结果呈阴性。 BKV 肾病于 1995 年首次报道，当时正值免疫抑制药物的广泛使用，这可能使 1-10% 的肾移植受者的核心病情复杂化。在免疫调节病毒（如巨细胞病毒感染）存在的情况下，发现细菌或真菌感染的存在也并不罕见。在此，我们描述了一名 67 岁的沙特男性，他出现肾功能恶化和不明原因发烧的症状，并被证明患有多瘤病毒肾病和播散性结核病。据我们所知，这是文献中首次报道此类协会。
Tuberculosis (TB) in renal transplant recipients presents important diagnostic difficulties because of the greater incidence of extra-pulmonary involvement, negative sputum smear results despite active disease and its atypical presentation, specifically reactivation of the latent form. BKV nephropathy was first reported in 1995, coinciding with the widespread use of immunosuppressive drugs, which can complicate the cores of 1-10% of renal transplant recipients. It is also not uncommon to find the existence of bacterial or fungal infections in the presence of an immuno-modulating virus like cytomegalovirus infection. Herewith, we describe a 67-year-old Saudi male who presented with deterioration of renal function and fever of unknown origin and was documented to have polyoma virus nephropathy and disseminated TB. To the best of our knowledge, this is the first report of such an association in the literature.