Shortvein, a new component of the decapentaplegic gene complex in Drosophila melanogaster.
Shortvein, a new component of the decapentaplegic gene complex in Drosophila melanogaster.
复制标题
短脉，果蝇十肢麻痹基因复合体的新组成部分。
DOI：
10.1093/genetics/109.1.119
复制
发表时间：
1985
期刊：
影响因子：
3.3
通讯作者：
Gelbart,WM
中科院分区：
文献类型：
--
作者：
Segal,D;Gelbart,WM
本实验室对果蝇十肢麻痹基因复合体（DPP-C）的结构和功能进行了研究。为了确定复合体的边界，我们研究了与先前发现的短脉突变（shv）等位的突变的遗传学，已知短脉突变位于十肢瘫痪患者附近。我们发现短脉位于Hin-dpp和dpp的远端，位于同一对多线染色体22 F1 -2中。损伤inshv不仅可以影响翅静脉的形成，但也可以干扰正常发育的部分成人和/或是致命的。像dpp突变体一样，hv相关的成人异常影响远端表皮结构。一些hvlesions导致幼虫致死综合征，这与异常长的幼虫阶段有关（约。是正常时间的五到六倍）。病变表现出一个涉及模式的互补与dpp突变，表明这两个shvanddpp部分的一个单一的基因复合体。shv/dpp反式杂合子显示的突变表型阵列的一个子集出现bedpp特异性表型，我们解释这些反映了certainshvalleles对dpp功能的失活效应。这些反式杂合子显示的其他异常似乎是shv特异性缺陷;我们认为这些表明某些突变对shv功能的失活作用。此外，DPP-C内的胚胎致死（EL）突变表现出与allshv突变的等位基因相互作用。我们的结论是，短脉区域代表了一个新发现的DPP-C的整合部分。
Our laboratory has been concerned with the structure and function of the decapentaplegic gene complex (DPP-C) inDrosophila melanogaster. To define the boundaries of the complex, we have studied the genetics of mutations allelic to a previously discovered mutation shortvein (shv), known to reside near decapentaplegic. We found that shortvein resides distal toHin-danddppwithin the same polytene chromosome doublet, 22F1-2. Lesions inshvcan affect not only the formation of the wing veins but also can interfere with normal development of parts of the adult and/or be lethal. Like those ofdppmutants, theshv-associated adult abnormalities affect distal epidermal structures. Someshvlesions cause a larval lethal syndrome which is associated with an unusually long larval stage (ca. five to six times its normal duration). Lesions inshvexhibit an involved pattern of complementation withdppmutations, indicating that bothshvanddppare parts of a single gene complex. A subset of the array of mutant phenotypes displayed byshv/dpp trans-heterozygotes appear to bedpp-specific phenotypes; we interpret these as reflecting an inactivation effect of certainshvalleles ondppfunctions. The other abnormalities displayed by thesetrans-heterozygotes appear to beshv-specific defects; we view these as indicating an inactivation effect of certaindppmutations onshvfunctions. Furthermore, embryonic lethal (EL) mutations within the DPP-C exhibit allelic interactions with allshvmutations. We conclude that the shortvein region represents a newly identified integrated portion of the DPP-C.