Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients
Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients
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DOI：
10.3109/09537101003628421
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发表时间：
2010-07
期刊：
影响因子：
3.3
通讯作者：
Y. Tavil;N. Şen;H. Yazıcı;M. Turfan;Fatma Hizal;A. Çengel;A. Abacı
中科院分区：
文献类型：
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作者：
Y. Tavil;N. Şen;H. Yazıcı;M. Turfan;Fatma Hizal;A. Çengel;A. Abacı
背景：平均血小板体积(MPV)是血小板活化的一个指标，而血小板活化是冠心病(CHD)病理生理过程中的中心过程。这项研究的目的有两个：一是确定糖尿病患者的MPV值是否增加，二是评估糖尿病并发症与MPV的关系。方法：研究对象为258例患者，分为两组。A组：2型糖尿病合并冠状动脉病变患者158例(女性78例，男性80例；平均年龄53.9~10.8岁；平均病程13.1~6.0岁)。对照组100例，女性48例，男性52例，平均年龄53.9~11岁。采用Gensini评分系统评价冠心病的延伸性。结果：患者组MPV为9.79±1.5fl，对照组为8.3±0.9fl，两组比较差异有统计学意义(P<0.001)。CHD的存在与MPV相关，优势比(95%CI)为2.31(1.55~4.42，p50.001)。结论：我们发现糖尿病合并冠心病患者的MPV值明显高于无糖尿病的对照组和冠状动脉造影正常的对照组。
Background: Mean platelet volume (MPV) is an indicator of platelet activation which is a central process in the pathophysiology of coronary heart disease (CHD). The aim of the study was twofold; first to determine whether MPV values is increased in patients with DM, and secondly to evaluate the relation between diabetic complications and MPV. Methods: The study population included 258 patients divided into two groups. Group A composed of 158 type 2 diabetic patients with coexistent coronary artery disease (stenotic lesions of 50%) (78 women, 80 men; mean age 53.9_10.8; mean diabetes duration 13.1_6.0). One hundred subjects (48 women, 52 men; mean age 53.9_11) without type 2 diabetes with normal coronary angiographies were taken as the control group (group B). To evaluate the extension of CHD, Gensini scoring system was used. Results: The MPV was significantly different in the patient group compared to the controls (9.79 ± 1.5 fl vs 8.3 ± 0.9 fl, P<0.001). The existence of CHD was associated with MPV with odds ratio (95% CI) of 2.31 (1.55–4.42, p50.001). Conclusion: We have found that diabetic patients with coronary heart disease have significantly higher MPV values compared to control subjects without diabetes and with angiographically normal coronary arteries.