Molecular Mechanisms of Cadherin Function During Cortical Migration.
Molecular Mechanisms of Cadherin Function During Cortical Migration.
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DOI：
10.3389/fcell.2020.588152
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发表时间：
2020
影响因子：
5.5
通讯作者：
Martinez-Garay I
中科院分区：
文献类型：
--
作者：
Martinez-Garay I
在大脑皮层的发育过程中，不同类型的神经元从不同的来源迁移到不同的皮层并在其中定居。在迁移的过程中，神经元利用其表面的细胞粘附分子与其他细胞相互作用，这些细胞将在确保迁移成功方面发挥关键作用。放射状迁移的投射神经元主要与放射状胶质细胞和Cajal-Retzius细胞相互作用，而起源于皮层下的中间神经元则遵循更长的切向路线，在到达皮层之前遇到额外的细胞底物。因此，细胞间的粘附对于皮层神经元的正确迁移至关重要。细胞粘附蛋白超家族的几个成员，通过钙依赖，主要是亲同源结合介导细胞相互作用，已被证明在投射神经元和中间神经元的神经元迁移中发挥重要作用。虽然有几种经典的钙粘蛋白和原钙粘蛋白参与这一过程，但最突出的是CDH2。本文将探讨钙粘蛋白在皮层迁移过程中的细胞和分子机制，包括通过调节钙粘蛋白表面水平来控制粘附强度的最新进展。
During development of the cerebral cortex, different types of neurons migrate from distinct origins to create the different cortical layers and settle within them. Along their way, migrating neurons use cell adhesion molecules on their surface to interact with other cells that will play critical roles to ensure that migration is successful. Radially migrating projection neurons interact primarily with radial glia and Cajal-Retzius cells, whereas interneurons originating in the subpallium follow a longer, tangential route and encounter additional cellular substrates before reaching the cortex. Cell-cell adhesion is therefore essential for the correct migration of cortical neurons. Several members of the cadherin superfamily of cell adhesion proteins, which mediate cellular interactions through calcium-dependent, mostly homophilic binding, have been shown to play important roles during neuronal migration of both projection neurons and interneurons. Although several classical cadherins and protocadherins are involved in this process, the most prominent is CDH2. This mini review will explore the cellular and molecular mechanisms underpinning cadherin function during cortical migration, including recent advances in our understanding of the control of adhesive strength through regulation of cadherin surface levels.