Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior.
Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior.
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DOI：
10.3233/bpl-150007
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发表时间：
2015-10-09
期刊：
影响因子：
--
通讯作者：
Mandyam CD
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文献类型：
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作者：
Somkuwar SS;Staples MC;Fannon MJ;Ghofranian A;Mandyam CD
初级保健机构对非法兴奋剂甲基苯丙胺成瘾和依赖的有效治疗的需求不断增加，但 FDA 尚未批准任何有效药物来减少依赖。这部分归因于成瘾各个阶段背后复杂而动态的神经生物学。治疗甲基苯丙胺成瘾的治疗策略，特别是成瘾的复发阶段，可能会彻底改变甲基苯丙胺成瘾的治疗。在这种情况下，临床前研究表明，自愿锻炼（持续的体力活动）可以作为减少甲基苯丙胺成瘾的干预措施。因此，甲基苯丙胺似乎会破坏大脑的正常功能，而这种破坏可以通过锻炼来预防或减少。本综述讨论了甲基苯丙胺成瘾和持续体力活动的动物模型，以及运动与甲基苯丙胺行为之间的相互作用。该综述强调了甲基苯丙胺和运动如何影响成年哺乳动物纹状体、海马体和前额皮质的神经元可塑性和神经毒性，并介绍了运动在减少甲基苯丙胺成瘾临床前模型中的摄入量和防止甲基苯丙胺复发方面的新机制。
The need for effective treatments for addiction and dependence to the illicit stimulant methamphetamine in primary care settings is increasing, yet no effective medications have been FDA approved to reduce dependence. This is partially attributed to the complex and dynamic neurobiology underlying the various stages of addiction. Therapeutic strategies to treat methamphetamine addiction, particularly the relapse stage of addiction, could revolutionize methamphetamine addiction treatment. In this context, preclinical studies demonstrate that voluntary exercise (sustained physical activity) could be used as an intervention to reduce methamphetamine addiction. Therefore, it appears that methamphetamine disrupts normal functioning in the brain and this disruption is prevented or reduced by engaging in exercise. This review discusses animal models of methamphetamine addiction and sustained physical activity and the interactions between exercise and methamphetamine behaviors. The review highlights how methamphetamine and exercise affect neuronal plasticity and neurotoxicity in the adult mammalian striatum, hippocampus, and prefrontal cortex, and presents the emerging mechanisms of exercise in attenuating intake and in preventing relapse to methamphetamine seeking in preclinical models of methamphetamine addiction.