Pegylated interferon‐alpha2a/ribavirin treatment of recurrent hepatitis C after liver transplantation
Pegylated interferon‐alpha2a/ribavirin treatment of recurrent hepatitis C after liver transplantation
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聚乙二醇干扰素-α2a/利巴韦林治疗肝移植术后复发性丙型肝炎
DOI：
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发表时间：
2009
影响因子：
2.6
通讯作者：
Francesco Negro
中科院分区：
文献类型：
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作者：
S. Dinges;I. Morard;Markus H. Heim;J. Dufour;Beat Müllhaupt;E. Giostra;P. Clavien;Gilles Mentha;Francesco Negro
Abstract: Hepatitis C virus (HCV) infection invariably recurs after liver transplantation (LT), leading to significant morbidity and mortality. Although the combination of pegylated interferon‐alpha (IFN‐α)/ribavirin is the preferred treatment for these patients, the optimal schedule remains undetermined. In an uncontrolled trial, 19 patients with HCV infection recurring after LT received pegylated IFN‐α2a, 180 μg weekly, and ribavirin, 10 mg/kg body weight daily, for 48 weeks. The proportion of patients with undetectable HCV RNA in their serum after 12 weeks of treatment was 53%. Five patients (26%) dropped out of the study due to intolerance (in 2 cases), depression (in 1), or infectious complications (in 2). A sustained virological response (SVR), defined as undetectable serum HCV RNA 24 weeks after the end of treatment, was observed in 9/19 patients (47%). SVR was associated with an early virological response after 12 weeks of therapy (P<0.001) and a treatment duration >80% (P=0.02), but not with baseline HCV RNA level or a cumulative dose of pegylated IFN‐α2a or ribavirin >80% of the scheduled dose. All 4 patients with genotype 2 or 3 reached SVR, as compared with 33% of patients with genotype 1 or 4 (P=0.03). A 48‐week course of pegylated IFN‐α2a/ribavirin therapy is effective in patients with recurrent HCV infection after LT.
用α干扰素治疗的肝移植受者急性同种异体移植排斥的发生率和严重程度。
DOI：
10.1002/lt.500040315
发表时间：
1998
期刊：
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
影响因子：
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作者：
Jain,A;Demetris,AJ;Manez,R;Tsamanadas,AC;VanThiel,D;Rakela,J;Starzl,TE;Fung,JJ
通讯作者：
Fung,JJ