Passive and active smoking and exhaled nitric oxide levels according to asthma and atopy in adults
Passive and active smoking and exhaled nitric oxide levels according to asthma and atopy in adults
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DOI：
10.1016/j.anai.2010.03.013
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发表时间：
2010-05-01
影响因子：
5.9
通讯作者：
Pin, Isabelle
中科院分区：
文献类型：
--
作者：
Nadif, Rachel;Matran, Regis;Pin, Isabelle
工作背景：没有关于呼出气一氧化氮分数（FeNO）水平在指导吸烟哮喘患者治疗中的效用的数据。识别吸烟的影响，在一个大的sample是need.Objective：研究吸烟和FeNO水平之间的关联，根据目前的哮喘和过敏状态的成年人从法国EGEA（流行病学研究的遗传学和环境的哮喘，支气管高反应性和过敏性）。记录了在家中、工作场所和休闲活动期间的主动吸烟和环境烟草烟雾（ETS）暴露。参与者被归类为没有暴露于ETS，轻度暴露（ETS = 2 h/d）。进行多变量分析，调整年龄，性别，身高，center.Results：平均调整后的FeNO值增加与哮喘（15.1与19.5 ppb），特应性（14.2与18.9 ppb），嗜酸性粒细胞增多症（15.8与24.8 ppb）（P <0.001）。平均FeNO水平随吸烟而降低（非吸烟者、既往吸烟者和当前吸烟者分别为18.4、17.5和14.5 ppb;趋势P = 0.001）。在非哮喘和哮喘参与者中观察到与吸烟的相关性，特别是在特应性哮喘参与者中。多变量分析显示，在非哮喘受试者中，ETS暴露至少2 h/d和主动吸烟与FeNO水平呈显著负相关，与年龄、性别、身高和中心无关（平均值[SE]，-0.13 [0.06]，P = 0.03和-0.10 [0.03]，P <0.001）和哮喘参与者（平均值[SE]，-0.18 [0.07]，P = 0.01和-0.14 [0.04]，P = 0.02）。结论：主动吸烟和被动吸烟降低了成人的FeNO水平。需要仔细考虑哮喘，特应性，主动和被动吸烟来解释FeNO值。Ann Allergy Asthma Immunol.2010;104：385-393.
Background: No data are available regarding the utility of fractional exhaled nitric oxide (FeNO) level in guiding therapy in smoking asthmatic patients. Identification of the effect of smoking in a large sample is needed.Objective: To study the association between smoking and FeNO level according to current asthma and atopy status in adults from the French EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy).Methods: Levels of FeNO were measured at 50 mL/s in 654 adults (268 asthmatic participants). Active smoking and environmental tobacco smoke (ETS) exposure at home, at work, and during leisure activities were recorded. Participants were categorized as having no exposure to ETS, mild exposure (ETS = 2 h/d). Multivariate analyses were performed, with adjustment for age, sex, height, and center.Results: Mean adjusted FeNO values increased with asthma (15.1 vs 19.5 ppb), atopy (14.2 vs 18.9 ppb), and eosinophilia (15.8 vs 24.8 ppb) (P < .001 for all). Mean FeNO levels decreased with smoking (18.4, 17.5, and 14.5 ppb in nonsmokers, ex-smokers, and current smokers, respectively; P for trend = .001). The association with smoking was observed in nonasthmatic and asthmatic participants, especially in atopic asthmatic participants. Multivariate analyses showed that ETS exposure of at least 2 h/d and active smoking were negatively and significantly associated with FeNO levels independent of age, sex, height, and center in nonasthmatic participants (mean [SE], -0.13 [0.06], P = .03 and -0.10 [0.03], P < .001) and in asthmatic participants (mean [SE], -0.18 [0.07], P = .01 and -0.14 [0.04], P = .02).Conclusions: Active and passive smoking decreased FeNO levels in adults. Careful consideration of asthma, atopy, and active and passive smoking are needed to interpret FeNO values. Ann Allergy Asthma Immunol. 2010;104:385-393.