Gastrectomy and risk of pancreatic cancer: systematic review and meta-analysis of observational studies
Gastrectomy and risk of pancreatic cancer: systematic review and meta-analysis of observational studies
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胃切除术和胰腺癌的风险：观察性研究的系统回顾和荟萃分析
DOI：
10.1007/s10552-012-0005-z
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发表时间：
2012-08-01
影响因子：
2.3
通讯作者：
Li, Zhihua
中科院分区：
文献类型：
--
作者：
Gong, Yuanfeng;Zhou, Quanbo;Li, Zhihua
目的探讨胃切除术与胰腺癌（PaC）发病的关系。方法：我们在Medline和EMBASE检索到2012年2月11日的符合条件的研究，以及关于该主题的原始研究和综述文章的参考文献列表。用随机效应模型计算总相对风险及其95%置信区间。采用cochranqand2统计方法评估研究间异质性。结果15项研究（11项病例对照研究和4项队列研究）符合入选标准。目前的数据显示，胃切除术与54%的PaC额外风险相关（SRRs = 1.54; 95% CI, 1.25-1.90；异质性检验q = 17.94,p< 0.001,I2= 22%）。本荟萃分析无发表偏倚。结论行胃切除术的患者发生PaC的风险明显增加，尤其是术后间隔较长的Billroth II切除术患者。
PurposeTo investigate the association between gastrectomy and risk of pancreatic cancer (PaC).MethodsWe identified eligible studies in Medline and EMBASE up to 11 February 2012 and the reference lists of original studies and review articles on this topic. Summary relative risks with their 95 % confidence intervals were calculated with a random-effects model. Between-study heterogeneity was assessed using CochranQandI2statistics.ResultsFifteen studies (11 case–control studies and 4 cohort studies) met eligibility criteria. The current data suggest that gastrectomy is associated with a 54 % excess risk of PaC (SRRs = 1.54; 95 % CI, 1.25–1.90; test for heterogeneityQ= 17.94,p< 0.001,I2= 22 %). There was no publication bias in the present meta-analysis.ConclusionA significant increased risk of PaC exists in patients who have undergone gastrectomy, particularly those receiving Billroth II resection with a long postoperative interval.