Hippocampal signals modify orbitofrontal representations to learn new paths.
Hippocampal signals modify orbitofrontal representations to learn new paths.
复制标题
海马信号修改眶额表征以学习新路径。
DOI：
10.1016/j.cub.2022.06.010
复制
发表时间：
2022
期刊：
影响因子：
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通讯作者：
Shapiro,MatthewL
中科院分区：
文献类型：
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作者：
Riceberg,JustinS;Srinivasan,Aditya;Guise,KevinG;Shapiro,MatthewL
We often remember the consequences of past choices to adapt to changing circumstances. Recalling past events requires the hippocampus (HPC), and using stimuli to anticipate outcome values requires the orbitofrontal cortex (OFC).1–3Spatial reversal tasks require both structures to navigate newly rewarded paths.4,5Both HPC place6and OFC value cells7,8fire in phase with theta (4–12 Hz) oscillations. Both structures are described as cognitive maps: HPC maps space9and OFC maps task states.10These similarities imply that OFC-HPC interactions are crucial for using memory to predict outcomes when circumstances change, but the mechanisms remain largely unknown. To investigate possible interactions, we simultaneously recorded ensembles in OFC and CA1 as rats learned spatial reversals in a plus maze. Striking interactions occurred only while rats learned their first reversal: CA1 population vectors predicted changes in OFC activity but not vice versa, OFC spikes phase locked to hippocampal theta oscillations, mixed pairs of CA1 and OFC neurons fired together within single theta cycles, and CA1 led OFC spikes by ∼30 ms. After the new contingency became familiar, CA1 ensembles stably represented distinct spatial paths, whereas OFC ensembles developed more generalized goal arm representations in different paths to identical rewards. These frontotemporal interactions, engaged selectively when new task features inform decision-making, suggest a mechanism for linking novel episodes with expected outcomes, when HPC signals trigger "cognitive remapping" by OFC.11
