Rapid diversification by recombination in Bartonella grahamii from wild rodents in Asia contrasts with low levels of genomic divergence in Northern Europe and America
Rapid diversification by recombination in Bartonella grahamii from wild rodents in Asia contrasts with low levels of genomic divergence in Northern Europe and America
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DOI：
10.1111/j.1365-294x.2010.04646.x
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发表时间：
2010-06-01
影响因子：
4.9
通讯作者：
Andersson, Siv G. E.
中科院分区：
文献类型：
--
作者：
Berglund, Eva C.;Ellegaard, Kirsten;Andersson, Siv G. E.
巴尔通体是一类媒介传播的细菌，可感染哺乳动物的红细胞，包括几种人类特有的和人畜共患的病原体。格雷哈米巴尔通体具有广泛的宿主范围，是野生啮齿动物中最常见的巴尔通体物种之一。我们研究了来自 7 个国家 11 种野生啮齿动物的 26 个 B. grahamii 菌株的种群结构、基因组含量和基因组可塑性。与之前分析的猫和人类相关的巴尔通体物种相比，我们发现格雷哈米氏杆菌具有强烈的地理模式、高重组频率和基因组大小的巨大变化。欧洲和北美的 B. grahamii 种群序列差异程度明显低于亚洲，并且预测亚洲菌株之间会发生一些重组事件。我们讨论可能导致观察到的差异的环境和人口因素。
Bartonella is a genus of vector-borne bacteria that infect the red blood cells of mammals, and includes several human-specific and zoonotic pathogens. Bartonella grahamii has a wide host range and is one of the most prevalent Bartonella species in wild rodents. We studied the population structure, genome content and genome plasticity of a collection of 26 B. grahamii isolates from 11 species of wild rodents in seven countries. We found strong geographic patterns, high recombination frequencies and large variations in genome size in B. grahamii compared with previously analysed cat- and human-associated Bartonella species. The extent of sequence divergence in B. grahamii populations was markedly lower in Europe and North America than in Asia, and several recombination events were predicted between the Asian strains. We discuss environmental and demographic factors that may underlie the observed differences.