Indole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute Infection
Indole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute Infection
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DOI：
10.1128/aac.02245-18
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发表时间：
2019-03-01
影响因子：
4.9
通讯作者：
North, E. Jeffrey
中科院分区：
文献类型：
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作者：
Pandya, Amit N.;Prathipati, Pavan K.;North, E. Jeffrey
非结核分枝杆菌（NTM）病原体特别感染患有结构性肺病的患者。我们以前报道过新的吲哚-2-甲酰胺（IC），对广泛的NTM病原体有活性。该研究公开了两种先导分子（化合物5和25）的体内数据，其在分枝杆菌感染的小鼠模型中进行了功效研究。经口给予铅分子可显著降低M.感染狂犬病的小鼠。
Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens. This study discloses in vivo data for two lead molecules (compounds 5 and 25) that were advanced for efficacy studies in Mycobacterium abscessus-infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial loads in lung and spleen of M. abscessus-infected mice.