TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease.
TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease.
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TGF-β/BAMBI 通路功能障碍导致慢性阻塞性肺疾病的外周 Th17/Treg 失衡。
DOI：
10.1038/srep31911
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发表时间：
2016-08-23
影响因子：
4.6
通讯作者：
Sun SW
中科院分区：
文献类型：
--
作者：
Zhang JC;Chen G;Chen L;Meng ZJ;Xiong XZ;Liu HJ;Jin Y;Tao XN;Wu JH;Sun SW
BMP和激活素膜结合抑制剂（BAMBI）被假定抑制或调节转化生长因子β（TGF-β）信号传导。此外，已经证明了慢性阻塞性肺病（COPD）肺组织体外感染后BAMBI表达的强烈上调。本研究旨在探讨TGF-β/BAMBI通路与COPD的关系。从27名健康对照（HC）、24名健康吸烟者（HS）和29名COPD患者获得血液样品。与HC和HS相比，在COPD中观察到Th 17/Treg比率升高，以及BAMBI蛋白和mRNA水平升高（分别在血浆和CD 4 + T细胞中）。BAMBI表达首先在人CD 4 + T细胞上观察到，具有典型的膜结合模式。COPD患者血浆BAMBI水平升高与血浆TGF-β1水平升高及Th 17/Treg比值升高呈正相关。总之，TGF-β/BAMBI通路受损可能促进炎症，导致Th 17/Treg失衡，这是吸烟者发展COPD的新机制。
BMP and activin membrane-bound inhibitor (BAMBI) is postulated to inhibit or modulate transforming growth factor β (TGF-β) signaling. Furthermore, strong upregulation of BAMBI expression following in vitro infection of chronic obstructive pulmonary disease (COPD) lung tissue has been demonstrated. In this study, we investigated whether TGF-β/BAMBI pathway is associated with COPD. Blood samples were obtained from 27 healthy controls (HC), 24 healthy smokers (HS) and 29 COPD patients. Elevated Th17/Treg ratios, and increased levels of BAMBI protein and mRNA (in plasma and CD4+ T cells respectively), were observed in COPD compared with HC and HS. BAMBI expression was first observed on human CD4+ T cells, with a typical membrane-bound pattern. The enhanced plasma BAMBI levels in COPD positively correlated with the increased plasma TGF-β1 levels and Th17/Treg ratio. Together, an impaired TGF-β/BAMBI pathway may promote the inflammation leading to Th17/Treg imbalance, which is a new mechanism in smokers who develop COPD.