LACTATE, 3-HYDROXYBUTYRATE, AND GLUCOSE AS SUBSTRATES FOR THE EARLY POSTNATAL RAT-BRAIN
LACTATE, 3-HYDROXYBUTYRATE, AND GLUCOSE AS SUBSTRATES FOR THE EARLY POSTNATAL RAT-BRAIN
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DOI：
10.1007/bf00964877
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发表时间：
1989-07-01
影响因子：
4.4
通讯作者：
CHAO, KL
中科院分区：
文献类型：
--
作者：
DOMBROWSKI, GJ;SWIATEK, KR;CHAO, KL
研究了出生后大脑能量代谢对葡萄糖、3-羟基丁酸和乳酸作为燃料来源的依赖性。6日龄哺乳仔猪大脑对葡萄糖的消耗很少，但到15日龄时，葡萄糖是主要的分解代谢产物。在出生6天或15天时，羟丁酸盐都不是主要的大脑燃料。在15日龄时，尽管血酮浓度接近最高值，但乳酸的利用仅占S大脑总能量需要量的19%。6日龄动物大脑代谢需求的70%由乳酸满足。在幼崽中，乳酸作为大脑代谢底物发挥的主要作用并不是由于血液乳酸浓度异常升高所致。幼年大脑中葡萄糖分解代谢缓慢的原因不是低内流率或酶能力不足。
The dependence of cerebral energy metabolism upon glucose, 3-hydroxybutyrate, and lactate as fuel sources during the postnatal period was investigated. The brain of 6 day old suckling pups used very little glucose, but by the 15th postnatal day glucose was the major catabolite. Hydroxybutyrate was not a major brain fuel at either 6 or 15 days of age. Its utilization accounted for only 19% of the brain''s total energy needs at 15 days of age, even though blood ketone concentrations are near maximal at this time. Seventy percent of the cerebral metabolic requirements were met by lactate in animals aged 6 days. The major role played by lactate as a substrate for brain metabolism in young pups was not a result of abnormally elevated blood lactate concentrations. The slow catabolism of glucose in young brain can not be explained by low rates of influx or inadequate enzymatic capacity.