Polymorphism at the porcine Dominant white/KIT locus influence coat colour and peripheral blood cell measures
Polymorphism at the porcine Dominant white/KIT locus influence coat colour and peripheral blood cell measures
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DOI：
10.1111/j.1365-2052.2005.01320.x
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发表时间：
2005-08-01
期刊：
影响因子：
2.4
通讯作者：
Edfors-Lilja, I
中科院分区：
文献类型：
--
作者：
Johansson, A;Pielberg, G;Edfors-Lilja, I
我们已经检查了不同KIT基因型的表型与毛色和几个血液参数（红细胞数量和测量，总白细胞和差异白细胞数量，红细胞压积和血红蛋白水平和血清成分）。两种不同的补铁方案（一次或两次铁注射）对血液参数的影响也进行了检查。对184头杂交仔猪（汉普郡、长白和约克郡的不同组合）在出生后一个月内进行了4次血液参数测定，并确定了这些仔猪和另外70头杂交仔猪的KIT基因型。鉴定出8种不同的KIT基因型，证实了商品猪群体中KIT位点的大等位基因多样性。结果表明，不同KIT基因型的猪在毛色和血液学参数上存在差异。总体而言，纯合子显性白（I/I）仔猪红细胞较大，血红蛋白浓度较低，提示轻度巨细胞性贫血。在I/I型仔猪中，两种铁注射比一种铁注射的效果也最为显著。
We have examined the phenotype of different KIT genotypes with regard to coat colour and several blood parameters (erythrocyte numbers and measures, total and differential leucocyte numbers, haematocrit and haemoglobin levels and serum components). The effect of two different iron supplement regimes (one or two iron injections) on the blood parameters was also examined. For a total of 184 cross-bred piglets (different combinations of Hampshire, Landrace and Yorkshire) blood parameters were measured four times during their first month of life, and the KIT genotypes of these and 70 additional cross-bred piglets were determined. Eight different KIT genotypes were identified, which confirms the large allelic diversity at the KIT locus in commercial pig populations. The results showed that pigs with different KIT genotypes differ both in coat colour and in haematological parameters. In general, homozygous Dominant white (I/I) piglets had larger erythrocytes with lower haemoglobin concentration, indicating a mild macrocytic anaemia. The effect of two compared with one iron injection was also most pronounced for the I/I piglets.