Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs.
Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs.
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DOI：
10.1016/j.biopsych.2009.08.040
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发表时间：
2010-02-01
影响因子：
10.6
通讯作者：
Ho, Beng-Choon
中科院分区：
文献类型：
--
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
用于比较不同药物剂量的标准化定量方法是设计临床试验和检查长期药物副作用（如迟发性运动障碍）影响的有用工具。这种方法需要确定剂量当量。一个专家共识小组已经发布了第一代和第二代药物的各种抗精神病药物的等效剂量图表。本研究中使用了这些图表。回归被用来比较专家图表中的每种药物与氯丙嗪和氟哌啶醇，并为每种关系创建公式。求解氯丙嗪100 mg和氟哌啶醇2 mg的公式，以获得新的氯丙嗪和氟哌啶醇等效物。这些公式被纳入我们的剂量-年定义中，因此服用100 mg/天氯丙嗪当量或2 mg/天氟哌啶醇当量1年等于1个剂量-年。与氯丙嗪和氟哌啶醇的所有比较均呈高度线性，R2值大于0.9。功率变换进一步改善了线性度。通过推导出一个独特的公式，将剂量转换为氯丙嗪或氟哌啶醇的当量，我们可以比较不同的药物。这些当量可以乘以个体接受给定剂量的时间，以得出以剂量-年为单位测量的累积值，其形式为（氯丙嗪当量（mg）×（剂量时间（年））。在将每个剂量转换为剂量年之后，可以将结果相加，以提供终生暴露的累积定量测量。
A standardized quantitative method for comparing dosages of different drugs is a useful tool for designing clinical trials and for examining the effects of long-term medication side effects such as tardive dyskinesia. Such a method requires establishing dose equivalents. An expert consensus group has published charts of equivalent doses for various antipsychotic medications for first- and second-generation medications. These charts were used in this study. Regression was used to compare each drug in the experts' charts to chlorpromazine and haloperidol and to create formulas for each relationship. The formulas were solved for chlorpromazine 100 mg and haloperidol 2 mg to derive new chlorpromazine and haloperidol equivalents. The formulas were incorporated into our definition of dose-years such that 100 mg/day of chlorpromazine equivalent or 2 mg/day of haloperidol equivalent taken for 1 year is equal to one dose-year. All comparisons to chlorpromazine and haloperidol were highly linear with R2 values greater than .9. A power transformation further improved linearity. By deriving a unique formula that converts doses to chlorpromazine or haloperidol equivalents, we can compare otherwise dissimilar drugs. These equivalents can be multiplied by the time an individual has been on a given dose to derive a cumulative value measured in dose-years in the form of (chlorpromazine equivalent in mg) × (time on dose measured in years). After each dose has been converted to dose-years, the results can be summed to provide a cumulative quantitative measure of lifetime exposure.
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