Mechanisms of Anemia in CKD
Mechanisms of Anemia in CKD
复制标题
DOI：
10.1681/asn.2011111078
复制
发表时间：
2012-10-01
影响因子：
13.6
通讯作者：
Lin, Herbert Y.
中科院分区：
文献类型：
--
作者：
Babitt, Jodie L.;Lin, Herbert Y.
贫血是CKD与不良结果相关的常见特征。 CKD中贫血患者的当前管理是有争议的，最近的临床试验表明，与促红细胞生成的刺激药物有关的发病率和死亡率增加。在这里，我们研究了最近对CKD贫血的分子机制的见解。这些见解对开发新的诊断测试和疗法的发展有望直接针对这种贫血形式的病理生理过程。
Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD. These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia.