Effects of chronic antidepressant drug administration and electroconvulsive shock on activity of dopaminergic neurons in the ventral tegmentum.
Effects of chronic antidepressant drug administration and electroconvulsive shock on activity of dopaminergic neurons in the ventral tegmentum.
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DOI：
10.1017/s1461145710000489
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Weiss JM
中科院分区：
文献类型：
--
作者：
West CH;Weiss JM
现在越来越多的注意力集中在前脑多巴胺能神经传递减少参与抑郁症。本论文评估是否有效的抗抑郁药（AD）治疗可能会抵消，或补偿，这种变化，通过改变腹侧被盖区（VTA-DA神经元）的多巴胺能神经元的神经元活性，中皮质边缘多巴胺能系统的细胞体。通过皮下植入的微型泵向大鼠施用八种AD药物或媒介物14天，此时在麻醉下记录VTA-DA神经元的单单位电生理活性。此外，动物接受了一系列的五个电休克（ECS）或控制程序，之后VTA-DA活动后，最后一个ECS的三天或五天进行了测量。结果表明，除单胺氧化酶抑制剂外，所有AD药物的长期给药均增加了VTA-DA神经元的自发放电率，而对“爆发”放电活动的影响则不太显著或一致。ECS增加VTA-DA神经元的自发放电率和爆发放电。这表明，观察到的影响是一致的报告增加多巴胺释放的区域，腹侧被盖区神经元有效的AD治疗后的项目。然而，它进一步表明，在腹侧被盖区-DA神经元活性的变化，在AD治疗应最适当的评估条件下与抑郁症，如应激条件。
Increasing attention is now focused on reduced dopaminergic neurotransmission in the forebrain as participating in depression. The present paper assessed whether effective antidepressant (AD) treatments might counteract, or compensate for, such a change by altering the neuronal activity of dopaminergic neurons in the ventral tegmental area (VTA-DA neurons), the cell bodies of the mesocorticolimbic dopaminergic system. Eight AD drugs or vehicle were administered to rats for 14 days via subcutaneously-implanted minipumps, at which time single-unit electrophysiological activity of VTA-DA neurons was recorded under anesthesia. Also, animals received a series of five electroconvulsive shocks (ECS) or control procedures, after which VTA-DA activity was measured either three or five days after the last ECS. Results showed that the chronic administration of all AD drugs tested except for the monoamine oxidase inhibitor increased the spontaneous firing rate of VTA-DA neurons, while effects on “burst” firing activity were found to be considerably less notable or consistent. ECS increased both spontaneous firing rate and burst firing of VTA-DA neurons. It is suggested that the effects observed are consistent with reports of increased dopamine release in regions to which VTA neurons project after effective AD treatment. However, it is further suggested that changes in VTA-DA neuronal activity in response to AD treatment should be most appropriately assessed under conditions associated with depression, such as stressful conditions.