Ce-TZP/Al2O3 nanocomposite as a bearing material in total joint replacement.
Ce-TZP/Al2O3 nanocomposite as a bearing material in total joint replacement.
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Ce-TZP/Al2O3 纳米复合材料作为全关节置换中的轴承材料。
DOI：
10.1002/jbm.10182
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Takashi Nakamura
中科院分区：
文献类型：
--
作者：
Kenji Tanaka;J. Tamura;K. Kawanabe;M. Nawa;M. Oka;M. Uchida;T. Kokubo;Takashi Nakamura
本研究的目的是研究新型Ce-TZP/Al(2O)O(3)纳米复合材料的生物相容性、相稳定性和磨损性能，并与传统陶瓷进行比较，以确定该复合材料是否可以用作全关节假体的轴承材料。在力学性能测试中，该复合材料表现出明显高于常规Y-TZP的韧性。为了进行生物相容性测试，将Ce-TZP/Al(2O)O(3)纳米复合材料和整体氧化铝的圆柱形样品植入雄性Wistar大鼠的椎旁肌。组织反应几乎相同，在植入后24周，两者周围均可见纤细的纤维囊膜，几乎没有炎症。两种陶瓷的膜厚度无显著差异。在121℃蒸汽中水热处理18h后，新复合材料表现出完全的抗老化性能，而Y-TZP的相变率为25.3vol%(初始为0.4%)，为单斜晶型。销盘试验结果表明，Ce-TZP/Al_2O_3纳米复合材料和氧化铝的磨损率分别为0.55+/-0.04×10(-7)mm(-7)和2.12+/-0.37×10(-7)mm(3)/Nm。研究结果表明，Ce-TZP/Al(2O)O(3)纳米复合材料是一种很有前途的人工关节替代陶瓷材料。
The objectives of this study were to investigate the biocompatibility, phase stability, and wear properties of a newly developed Ce-TZP/Al(2)O(3) nanocomposite, as compared to conventional ceramics, and to determine whether the new composite could be used as a bearing material in total joint prostheses. In tests of mechanical properties, this composite showed significantly higher toughness than conventional Y-TZP. For biocompatibility tests, cylindrical specimens of both the Ce-TZP/Al(2)O(3) nanocomposite and monolithic alumina were implanted into the paraspinal muscles of male Wistar rats. The tissue reactions were almost the same, and at 24 weeks after implantation, thin fibrous capsules with almost no inflammation were observed around both of them. There were no significant differences in membrane thickness between the two ceramics. After hydrothermal treatment in 121 degrees C vapor for 18 h, the new composite showed complete resistance to aging degradation, whereas Y-TZP showed a phase transformation of 25.3 vol% (initial 0.4%) to the monoclinic form. According to the results of pin-on-disk tests, the wear rates of Ce-TZP/Al(2)O(3) nanocomposite and alumina were 0.55 +/- 0.04 x 10(-7) and 2.12 +/- 0.37 x 10(-7)mm(3)/Nm, respectively. The results of this study suggest that the Ce-TZP/Al(2)O(3) nanocomposite is a promising alternative ceramic component for total joint replacement.