Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease
Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease
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DOI：
10.1159/000017068
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发表时间：
1998-09-01
影响因子：
2.4
通讯作者：
Nakashima, K
中科院分区：
文献类型：
--
作者：
Ji, Y;Urakami, K;Nakashima, K
载脂蛋白E ε 4等位基因（ApoE ε 4）与家族性和散发性阿尔茨海默病（AD）相关，但ApoE ε 4等位基因与血管性痴呆（VD）和/或缺血性脑血管病（ICVD）的相关性仍存在争议。为了阐明ApoE多态性与日本人AD、VD和ICVD的关系，我们检测了255例AD患者、87例VD患者和123例ICVD患者的ApoE多态性，并与117例年龄匹配的健康对照组（CTL）进行比较。AD组、VD组和ICVD组ApoE基因频率分别为0.21、0.15和0.26，均显著高于CTL组（0.08）。提示ApoE β 4基因型不仅与AD有关，而且与VD和ICVD有关，ApoE β 4在痴呆和ICVD的发生发展中起重要作用。
Apolipoprotein E epsilon 4 allele (ApoE epsilon 4) is associated with Alzheimer's disease (AD) in familial and sporadic cases, but the associations of ApoE epsilon 4 allele and vascular dementia (VD) and/or ischemic cerebrovascular disease (ICVD) are still controversial. To clarify the associations of ApoE polymorphism with AD, VD and ICVD in Japanese, we examined ApoE polymorphism in samples of 255 patients with AD, 87 patients with VD, and 123 patients with ICVD, as compared with 117 age-matched healthy control subjects (CTL). The frequency of the ApoE epsilon 4 allele was significantly higher in the VD group (0.21), the ICVD group (0.15) as well as in the AD group (0.26) than in the CTL subjects (0.08). These findings suggest that the genotype of ApoE epsilon 4 is associated with not only AD but also VD and ICVD, and that ApoE epsilon 4 plays an important role in the development of dementia and ICVD.