Predictors for early diagnosis of cerebral palsy from national registry data
Predictors for early diagnosis of cerebral palsy from national registry data
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DOI：
10.1111/dmcn.12760
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发表时间：
2015-10-01
影响因子：
3.8
通讯作者：
Uldall, Peter
中科院分区：
文献类型：
--
作者：
Granild-Jensen, Jakob Bie;Rackauskaite, Gija;Uldall, Peter
目的脑性瘫痪（脑瘫）的早期干预是重要的，早期诊断是必要的.本研究的目的是建立CP的中位数诊断年龄，并确定在人口为基础的coherent.MethodUsing丹麦国家脑瘫登记处（NCPR）的早期诊断的预测因素，我们确定了1291名儿童与CP（764名男性，527名女性）出生于1995年和2003年之间。诊断日期定义为父母被告知他们的孩子患有痉挛或CP的日期。我们计算了诊断的年龄，并分析了以下预测因素：类型的CP，运动障碍的程度，脑超声检查结果，癫痫，胎龄，和认知功能障碍的程度。ResultsWe发现整体的中位数校正诊断年龄CP为11个月。早期诊断与CP的类型、癫痫的存在、高度的运动障碍和脑超声检查的异常有关。孕龄与诊断年龄无关。InterpretationThe中位数诊断年龄意味着一半的丹麦CP儿童将能够在1岁之前进入早期干预计划。晚诊断与不严重的症状有关，孕龄不影响诊断年龄。
AimAs early intervention is important in cerebral palsy (CP), an early diagnosis is desirable. The aim of this study was to establish the median diagnostic age of CP and to identify predictors of an early diagnosis in a population-based cohort.MethodUsing the Danish National Cerebral Palsy Registry (NCPR), we identified 1291 children with CP (764 males, 527 females) born between 1995 and 2003. The date of diagnosis was defined as the day the parents were told that their child was spastic or had CP. We calculated the age of diagnosis and analysed the following predictors: type of CP, degree of motor disability, cerebral ultrasonography results, epilepsy, gestational age, and degree of cognitive impairment.ResultsWe found the overall median corrected diagnostic age of CP to be 11months. Early diagnosis was associated with the type of CP, presence of epilepsy, a high degree of motor disability, and abnormalities in the cerebral ultrasonography. The gestational age was not associated with the diagnostic age.InterpretationThe median diagnostic age implies that half of the Danish children with CP will be able to enter an early intervention program before 1year of age. A late diagnosis was associated with less severe symptoms, and gestational age did not influence the diagnostic age.