A new sesquiterpene, a new monoterpene and other constituents with anti-inflammatory activities from the roots of Aristolochia debilis
A new sesquiterpene, a new monoterpene and other constituents with anti-inflammatory activities from the roots of Aristolochia debilis
复制标题
来自马兜铃根的新型倍半萜、新型单萜及其他具有抗炎活性的成分
DOI：
10.1080/14786419.2018.1532425
复制
发表时间：
2020-02-01
影响因子：
2.2
通讯作者：
Li, Gao
中科院分区：
文献类型：
--
作者：
Wang, Xin;Jin, Mei;Li, Gao
A new sesquiterpene (1) and a new monoterpene (2), together with thirteen known compounds (3-15) were isolated from an ethanol extract of the roots of Aristolochia debilis Sieb. et Zucc. The structures of compounds 1 and 2 were elucidated using HR-ESI-MS, 1D and 2D NMR spectroscopy. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of nitric oxide, tumour-necrosis factor-alpha and interleukin-6 production in lipopolysaccharide-stimulated RAW264.7 cells. Compounds 1-9 and 12-15 significantly inhibited the levels of NO, TNF-alpha and IL-6 in LPS-induced RAW264.7 cells from concentrations of 3 mu M to 30 mu M.
