Comparison of aorta and pulmonary artery: II. LDL transport and metabolism correlate with susceptibility to atherosclerosis.
Comparison of aorta and pulmonary artery: II. LDL transport and metabolism correlate with susceptibility to atherosclerosis.
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DOI：
10.1161/01.res.81.3.346
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发表时间：
1997-09
影响因子：
20.1
通讯作者：
D. Schwenke
中科院分区：
文献类型：
--
作者：
D. Schwenke
兔子的肺动脉和主动脉同样容易发生动脉粥样硬化。然而，造成这种现象的机制尚不清楚。本研究调查了以下假设：动脉低密度脂蛋白 (LDL) 转运和代谢的一个或多个方面可能解释主动脉弓和肺动脉对动脉粥样硬化的相似易感性，以及与胸降主动脉相比这些动脉区域的易感性增加。我们测定了正常兔子和喂食胆固醇大约 8 天的兔子的内膜中层对 LDL 的渗透性、LDL 降解率和未降解的 LDL 浓度。正常兔子和饲喂胆固醇8天的兔子相应动脉区域的内膜中层通透性没有差异，并且主动脉弓和肺动脉的内膜中层通透性相似。内膜中层的 LDL 降解率和未降解 LDL 浓度受到胆固醇喂养的影响。由于高胆固醇血症，这些测量值的分数项有所减少，但绝对值有所增加，而肺动脉和主动脉弓的相应参数之间没有差异。然而，与胸降主动脉相比，主动脉弓内膜中层的 LDL 通透性、LDL 降解率和未降解 LDL 浓度均增加。肺动脉和胸降主动脉的比较也有类似的趋势，尽管并不总是显着。 LDL 转运和代谢的差异以及喂食胆固醇 8 天后的变化与所研究的三个动脉区域对动脉粥样硬化的相对易感性平行。这些结果支持动脉低密度脂蛋白转运和代谢在动脉粥样硬化形成中的作用，并可能为这三个动脉区域动脉粥样硬化易感性的差异提供机制解释。
The pulmonary artery and the aorta are similarly susceptible to atherosclerosis in rabbits. However, the mechanism(s) that accounts for this is not yet known. This study investigated the hypothesis that one or more aspects of arterial low-density lipoprotein (LDL) transport and metabolism might explain the similar susceptibility of the aortic arch and pulmonary artery to atherosclerosis and the increased susceptibility of these arterial regions compared with the descending thoracic aorta. We determined permeability to LDL, rates of LDL degradation, and concentrations of undegraded LDL for the intima-media of normal rabbits and those fed cholesterol for approximately 8 days. Intima-media permeability did not differ between corresponding arterial regions of normal rabbits and rabbits fed cholesterol for 8 days and was similar for the aortic arch and pulmonary artery. Rates of LDL degradation and concentrations of undegraded LDL for the intima-media were influenced by cholesterol feeding. These measures were reduced in fractional terms but increased in absolute terms as a result of hypercholesterolemia, without differences between corresponding parameters for the pulmonary artery and aortic arch. However, permeability to LDL, rates of LDL degradation, and concentrations of undegraded LDL were increased for the intima-media of the aortic arch compared with the descending thoracic aorta. Similar, although not always significant, trends were evident for the comparison of the pulmonary artery and descending thoracic aorta. Differences in LDL transport and metabolism and changes after feeding cholesterol for 8 days parallel the relative susceptibility to atherosclerosis for the three arterial regions studied. These results support the role of arterial LDL transport and metabolism in atherogenesis and potentially provide a mechanistic explanation for the differences in susceptibility to atherosclerosis for these three arterial regions.