Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation

Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation
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DOI:
10.1039/c0sc00524j
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发表时间:
2011-01-01
期刊:
影响因子:
8.4
通讯作者:
Buchwald, Stephen L.
Buchwald, Stephen L.
中科院分区:
化学1区
文献类型:
--
作者:
Noel, Timothy;Naber, John R.;Buchwald, Stephen L.

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通过声辐射有效处理固体,使连续流钯催化胺化反应成为可能。反应时间从 20 秒到 10 分钟不等,得到了各种二芳基胺。
A continuous-flow palladium-catalyzed amination reaction was made possible through efficient handling of solids via acoustic irradiation. Various diarylamines were obtained with reaction times ranging from 20 s to 10 min.