Cardiovascular health and cognitive functioning among centenarians: a comparison between the Tokyo and Georgia centenarian studies
Cardiovascular health and cognitive functioning among centenarians: a comparison between the Tokyo and Georgia centenarian studies
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DOI：
10.1017/s1041610218001813
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发表时间：
2019-04-01
影响因子：
7
通讯作者：
Hirose, Nobuyoshi
中科院分区：
文献类型：
--
作者：
Martin, Peter;Gondo, Yasuyuki;Hirose, Nobuyoshi
研究目的：百岁老人能活到很晚，但他们是否能健康地活到很老仍然不清楚。本研究的目的是比较美国百岁老人与日本百岁老人的心血管健康状况和认知功能。美国百岁老人的样本是从格鲁吉亚百岁老人研究中招募的，包括287名百岁老人。日本百岁老人的样本是从东京百岁老人研究中招募的，包括304名百岁老人。测量：认知功能用精神状态问卷进行评估，心血管疾病通过健康史评估，血压和选定的血液参数进行评估。结果：结果表明，与格鲁吉亚百岁老人相比，东京百岁老人的疾病经历和BMI值较低，但日本百岁老人的血压更高。日本百岁老人的血红蛋白水平较低，而格鲁吉亚的C-反应蛋白水平较高，这两个国家的高血压和白蛋白水平与认知功能呈正相关，而脑卒中的发生与认知功能呈负相关。心脏问题，体重指数和C-反应蛋白（东京百岁老人的积极影响，除了C-反应蛋白）的差异效果。结论：对于非常老的人，心血管疾病的一些标志物是可复制的国家之间，而心血管健康的差异影响也需要考虑在心血管健康。
Objectives: Centenarians have survived into very late life, but whether they reach very old age in good health remains unclear. The purpose of this study was to compare the cardiovascular health status and cognitive functioning of centenarians in the United States with centenarians in Japan.Design, Setting, and Participants: This cross-national design compared centenarians from the United States and Japan. The sample of U.S. centenarians was recruited from the Georgia Centenarian Study and included 287 centenarians. The sample of Japanese centenarians was recruited from the Tokyo Centenarian Study and included 304 centenarians.Measurements: Cognitive functioning was assessed with a mental status questionnaire, and cardiovascular disease by a health history assessment, blood pressure, and selected blood parameters.Results: The results suggest that Tokyo centenarians had lower disease experiences and BMI values, when compared to Georgia centenarians, but blood pressure was higher among Japanese centenarians. Lower levels of hemoglobin in Japanese centenarians and higher levels of C-reactive protein in Georgia were also found. The positive association of hypertension and albumin levels with cognitive functioning and the negative association of stroke occurrence with cognitive functioning were replicated in both countries. Differential effects were obtained for heart problems, BMI, and C-reactive protein (with positive effects for Tokyo centenarians, except for C-reactive protein).Conclusion: For extremely old individuals, some markers of cardiovascular disease are replicable across countries, whereas differential effects for cardiovascular health also need to be considered in cardiovascular health.