PFOA is associated with diabetes and metabolic alteration in US men: National Health and Nutrition Examination Survey 2003-2012
PFOA is associated with diabetes and metabolic alteration in US men: National Health and Nutrition Examination Survey 2003-2012
复制标题
PFOA 与美国男性糖尿病和代谢改变相关：2003-2012 年国家健康和营养检查调查
DOI：
10.1016/j.scitotenv.2017.12.186
复制
发表时间：
2018-06-01
影响因子：
9.8
通讯作者：
Tang, Wei
中科院分区：
文献类型：
--
作者：
He, Xiaowei;Liu, Yuanxin;Tang, Wei
接触全氟烷基物质(全氟烷基物质)与一系列有害健康影响有关。然而，目前尚不清楚环境相关暴露水平的全氟辛烷磺酸是否与成人的糖尿病和代谢物浓度有关。使用2003-2012年国家健康和营养检查调查(NHANES)中7904名成年人(年龄=20岁)的横断面数据，我们检验了PFAS与糖尿病患病率和代谢物浓度的关系。用多因素Logistic回归分析血清全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)、全氟己烷磺酸(PFHxS)和全氟农酸盐(PFNA)水平与糖尿病患病率的关系。进一步进行了多变量广义线性回归，以研究PFAS暴露与某些代谢物之间的关系。我们发现，在调整模型的男性中，血清全氟辛酸与糖尿病患病率之间存在很强的正相关关系(OR：2.66，95%CI：1.63-4.35；趋势P=0.001)。未观察到血清全氟辛酸与女性糖尿病患病率的显著关联(OR：1.47，95%CI：0.88-2.46；趋势P=0.737)。此外，无论性别，糖尿病与全氟辛烷磺酸、全氟辛烷磺酸和全氟辛烷磺酸无关。在性别分层的广义线性模型中，与全氟辛酸水平最低的人相比，全氟辛酸水平最高的男性和女性的血清总胆固醇增加了1.43%(95%可信区间：0.62%-2.34%)和1.07%(95%可信区间：0.27%-1.97%)(趋势P=0.006和0.001)。血清全氟辛酸与其他代谢物之间没有显著的相关性。这些结果提供了流行病学证据，表明与环境有关的血清全氟辛酸水平可能与男性糖尿病的患病率和成年人的总胆固醇呈正相关。迫切需要进一步的临床和动物研究来阐明推定的因果关系，并阐明潜在的作用模式。(C)2017年，由爱思唯尔出版。
Exposure to perfluoroalkyl substances (PFAS) is associated with a range of adverse health effects. However, it remains unclear whether PFAS at environmentally relevant exposure levels are related to diabetes and metabolite concentrations in adults. Using cross-sectional data from 7904 adults (age >= 20 years) in the 2003-2012 National Health and Nutrition Examination Survey (NHANES), we examined the association of PFAS with the prevalence of diabetes and metabolite concentrations. A multivariate logistic regression was applied to investigate the associations of diabetes prevalence with serum perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS) and perfluorononanoate (PFNA) levels. A multivariate generalised linear regression was further performed to investigate the associations between PFAS exposure and some metabolites. We identified a strong positive association between serum PFOA and diabetes prevalence in men with an adjusted model (OR: 2.66, 95% CI: 1.63-4.35; P for trend = 0.001). No significant association between serum PFOA and diabetes prevalence was observed in women (OR: 1.47, 95% CI: 0.88-2.46; P for trend = 0.737). Furthermore, diabetes was not related to PFOS, PFHxS and PFNA, regardless of gender. In the gender-stratified generalised linear models, men and women with the highest PFOA levels demonstrated a 1.43% (95% CI: 0.62%-2.34%) and a 1.07% (95% CI: 0.27%-1.97%) greater increase in serumtotal cholesterol (P for trend= 0.006 and 0.001) compared to those with the lowest PFOA levels. There were no significant associations between serum PFOA and other metabolites. These results provide epidemiological evidence that environment-related levels of serum PFOA may be positively associated with the prevalence of diabetes in men and with total cholesterol in adults. Further clinical and animal studies are urgently needed to elucidate putative causal relationships and shed light on the potential mode of action involved. (C) 2017 Published by Elsevier B.V.