Assessment of Left Ventricular Pre-Ejection Period in the Fetus Using Simultaneous Magnetocardiography and Echocardiography
Assessment of Left Ventricular Pre-Ejection Period in the Fetus Using Simultaneous Magnetocardiography and Echocardiography
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DOI：
10.1159/000318345
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Strasburger, Janette F.
中科院分区：
文献类型：
--
作者：
Mensah-Brown, Nana Aba;Wakai, Ronald T.;Strasburger, Janette F.
简介：胎儿心磁图（fMCG）是一种很有前途的新技术，用于评估胎儿的节奏，但是，没有以前的研究利用fMCG来评估人类胎儿的机电生理。射血前期（PEP）是心脏的机电激活的重要量度，并且被疾病状态和心律失常改变。材料与方法：一种新的技术被用来评估胎儿PEP及其与其他胎儿心脏收缩时间间期，RR间期和胎龄（GA）的关系。应用脉冲多普勒超声和fMCG同步检测了25例孕19 ~ 38周的正常胎儿。PEP、射血时间、QRS宽度和RR间期之间的相关性采用线性回归进行评估。结果如下：在所有受试者中，发现PEP与GA（R = 0.57，p < 0.0001）、QRS宽度（R = 0.35，p = 0.026）和RR间期（R = 0.37，p = 0.018）相关。在个别会话中，PEP与前一个RR间期呈负相关。结论：PEP的发育趋势为了解人胎心脏的正常发育提供了依据。版权所有（C）2010 S. Karger AG，巴塞尔
Introduction: Fetal magnetocardiography (fMCG) is a promising new technique for assessing fetal rhythm; however, no prior studies have utilized fMCG to evaluate human fetal electromechanical physiology. Pre-ejection period (PEP) is an important measure of the electromechanical activation of the heart, and is altered by disease states and arrhythmias. Materials and Methods: A novel technique was used to assess fetal PEP and its relationship to other fetal systolic time intervals, RR interval, and gestational age (GA). 25 normal human fetuses between 19 and 38 weeks' gestation were studied using simultaneous pulsed Doppler ultrasound and fMCG. Correlations among PEP, ejection time, QRS width and RR interval were assessed using linear regression. Results: Across all subjects, PEP was found to correlate with GA (R = 0.57, p < 0.0001), QRS width (R = 0.35, p = 0.026), and RR interval (R = 0.37, p = 0.018). In individual sessions, PEP negatively correlated beat-to-beat with the preceding RR interval. Conclusion: PEP exhibits developmental trends that provide a better understanding of the normal development of the human fetal heart. Copyright (C) 2010 S. Karger AG, Basel