Letter regarding article by Rademaker et al, "integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure".
Letter regarding article by Rademaker et al, "integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure".
复制标题
关于 Rademaker 等人的文章“尿皮质素 2 在正常和起搏绵羊中的综合血流动力学、激素和肾脏作用：对心力衰竭的有益作用”的信件。
作者：
Kazuhiro Takahashi
致编辑：
我怀着极大的兴趣阅读了Rademaker等人1的研究报告，报告了尿皮质素2对起搏引起心力衰竭的绵羊有益的心血管和体液作用。Urocortin 2是一种有效的血管扩张肽，特异性作用于促肾上腺皮质激素释放因子2型受体。Rademaker等人1的研究表明，这种肽可能对心力衰竭患者具有治疗潜力。然而，我想提醒读者，尿皮质素2肽在人体组织（包括心脏）中的存在迄今尚未确定。如果人尿皮质素2不是内源性肽，则施用真实肽可能在人受试者中引起过敏反应。…
To the Editor:
I read with great interest the study by Rademaker et al1 reporting the beneficial cardiovascular and humoral effects of urocortin 2 in sheep with heart failure induced by pacing. Urocortin 2 is a potent vasodilator peptide that acts specifically on the corticotropin-releasing factor type 2 receptor. The study by Rademaker et al1 suggests that this peptide may have therapeutic potential in patients with heart failure. However, I would like to remind the readers that the presence of urocortin 2 peptide in human tissues, including the heart, has not been established so far. If human urocortin 2 is not an endogenous peptide, the administration of the authentic peptide may cause allergic responses in human subjects. …