Phenotypical resistance correlation networks for 10 non-typhoidal Salmonella subpopulations in an active antimicrobial surveillance programme
Phenotypical resistance correlation networks for 10 non-typhoidal Salmonella subpopulations in an active antimicrobial surveillance programme
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DOI：
10.1017/s0950268818000833
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发表时间：
2018-06-01
影响因子：
4.2
通讯作者：
Lanzas, C.
中科院分区：
文献类型：
--
作者：
Love, W. J.;Zawack, K. A.;Lanzas, C.
抗菌药物在治疗侵袭性非伤寒沙门氏菌病（iNTS）和其他疾病方面发挥着关键作用，但耐药病原体阻碍了疗效。表型抗性的选择可以通过几种机制发生。目前的研究旨在确定相关性，这将允许间接选择增加耐头孢曲松，环丙沙星和阿奇霉素，以改善抗菌药物的管理。这些是治疗iNTS的医学上重要的抗生素，但这些耐药性在非伤寒沙门氏菌血清型中持续存在，即使它们没有被许可用于美国食用动物。根据血清型和宿主种属将国家抗菌药物耐药性监测系统从动物源中收集的2875株肠道沙门氏菌分离株分为10个亚群。用最小抑菌浓度偏相关网络模型估计各亚群的侧支抗性。头孢曲松敏感性与其他β-内酰胺类耐药相关，对四环素、甲氧苄啶-磺胺甲恶唑或卡那霉素的耐药较少。阿奇霉素耐药常与氯霉素耐药相关。通过间接选择环丙沙星耐药性似乎不太可能。ACSSuT子图电阻的密度与表型频率一致。目前的研究确定了iNTS血清型中的几种重要耐药性，需要进一步研究以确定致病遗传相关性。
Antimicrobials play a critical role in treating cases of invasive non-typhoidal salmonellosis (iNTS) and other diseases, but efficacy is hindered by resistant pathogens. Selection for phenotypical resistance may occur via several mechanisms. The current study aims to identify correlations that would allow indirect selection of increased resistance to ceftriaxone, ciprofloxacin and azithromycin to improve antimicrobial stewardship. These are medically important antibiotics for treating iNTS, hut these resistances persist in non-Typhi Salmonella serotypes even though they are not licensed for use in US food animals. A set of 2875 Salmonella enterica isolates collected from animal sources by the National Antimicrobial Resistance Monitoring System were stratified in to 10 subpopulations based on serotype and host species. Collateral resistances in each subpopulation were estimated as network models of minimum inhibitory concentration partial correlations. Ceftriaxone sensitivity was correlated with other beta-lactam resistances, and less commonly resistances to tetracycline, trimethoprim-sulfamethoxazole or kanamycin. Azithromycin resistance was frequently correlated with chloramphenicol resistance. Indirect selection for ciprofloxacin resistance via collateral selection appears unlikely. Density of the ACSSuT subgraph resistance aligned well with the phenotypical frequency. The current study identifies several important resistances in iNTS serotypes and further research is needed to identify the causative genetic correlations.