The Expression of 11β-HSDs, GR, and H6PDH in Subcutaneous Adipose Tissue from Polycystic Ovary Syndrome Subjects
The Expression of 11β-HSDs, GR, and H6PDH in Subcutaneous Adipose Tissue from Polycystic Ovary Syndrome Subjects
复制标题
多囊卵巢综合征受试者皮下脂肪组织中 11β-HSD、GR 和 H6PDH 的表达
DOI：
10.1055/s-0033-1345186
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发表时间：
2013-10-01
影响因子：
2.2
通讯作者：
Liu, W.
中科院分区：
文献类型：
--
作者：
Li, S.;Tao, T.;Liu, W.
本研究的目的是探讨11-羟基类固醇脱氢酶（11-HSD）1型和2型、6-磷酸己糖脱氢酶（H6 PDH）和糖皮质激素受体（GR）mRNA在肥胖伴或不伴多囊卵巢综合征（PCOS）妇女皮下脂肪组织（SAT）中的表达及其与脂肪细胞因子浓度之间的关系。16名PCOS妇女（P组）和18名年龄和BMI匹配的对照妇女（C组）参加了这项研究。从腹部采集皮下脂肪组织。实时荧光定量PCR检测基因表达，ELISA检测脂肪细胞因子浓度。采用胰岛素抵抗稳态评估模型（HOMA-IR）评估外周血胰岛素敏感性。通过稳态模型评估β细胞功能（HOMA-IS）来评估β细胞功能。PCOS组11-HSD 1 mRNA表达显著高于正常对照组（p
The aim of the work was to investigate the expression of 11-hydroxysteroid dehydrogenase (11-HSD) type 1 and 2, hexose-6-phosphate dehydrogenase (H6PDH), and glucocorticoids receptor (GR) mRNA in subcutaneous adipose tissue (SAT) from obese women with or without polycystic ovary syndrome (PCOS), and the association between their expression and the adipocytokines' concentration. Sixteen women with PCOS (group P) and 18 age- and BMI-matched control women (group C) were enrolled for the study. Subcutaneous adipose tissue was collected from the abdomen. The genes' expression was detected by real-time PCR, and the adipocytokines' concentration was measured by ELISA. Peripheral insulin sensitivity was assessed by homeostatic assessment model of insulin resistance (HOMA-IR). -cell function was assessed by homeostasis model assessment of -cell function (HOMA-IS). The expression of 11-HSD1 mRNA was significantly higher in PCOS subjects (p