Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines
Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines
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硫脲与甲醛和环胺的氨甲基化反应
DOI：
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发表时间：
2018
影响因子：
0.8
通讯作者：
E. S. Khrabrova
中科院分区：
文献类型：
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作者：
Yu. A. Martinovich;S. M. Ramsh;Fares Hamoud;V. S. Fundamenskii;V. V. Gurzhii;V. Zakharov;E. S. Khrabrova
硫脲与等摩尔量的甲醛和吗啉的三组分缩合得到N-(吗啉-4-基甲基)衍生物，而与2当量的甲醛和胺的类似反应得到对称的N,N'-双(吗啉-4-基甲基)硫脲。在硫脲与哌啶和甲醛的缩合反应中，无论反应物比例如何，仅分离出对称的N,N'-双(哌啶-1-基甲基)硫脲。
Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N-(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N,N′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless of the reactant ratio.