Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens.
Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens.
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DOI：
10.1155/2016/2475067
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发表时间：
2016
影响因子：
--
通讯作者：
Indrawattana N
中科院分区：
文献类型：
--
作者：
Santajit S;Indrawattana N
ESKAPE病原体（屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）是全世界医院感染的主要原因。其中大多数是多重耐药菌株，这是临床实践中最大的挑战之一。多药耐药性是全球公共卫生面临的三大威胁之一，通常是由过度使用药物或处方、不适当使用抗菌药物和不合格药物引起的。了解这些细菌的耐药机制对于开发新型抗菌剂或其他替代工具来应对这些公共卫生挑战至关重要。更深入的机制理解也将有助于预测潜在的甚至未知的耐药机制，这可以应用于其他新兴的多药耐药病原体。本文就ESKAPE病原菌的耐药机制进行综述。
The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are the leading cause of nosocomial infections throughout the world. Most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. Multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate use of antimicrobials, and substandard pharmaceuticals. Understanding the resistance mechanisms of these bacteria is crucial for the development of novel antimicrobial agents or other alternative tools to combat these public health challenges. Greater mechanistic understanding would also aid in the prediction of underlying or even unknown mechanisms of resistance, which could be applied to other emerging multidrug resistant pathogens. In this review, we summarize the known antimicrobial resistance mechanisms of ESKAPE pathogens.