One-carbon metabolism and breast cancer: an epidemiological perspective.
One-carbon metabolism and breast cancer: an epidemiological perspective.
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DOI：
10.1016/s1673-8527(08)60108-3
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发表时间：
2009-04
影响因子：
5.9
通讯作者：
Chen, Jia
中科院分区：
文献类型：
--
作者：
Xu, Xinran;Chen, Jia
一碳代谢是一个生物反应网络，在DNA甲基化和DNA合成中发挥关键作用，进而促进遗传和表观遗传过程之间的相互作用。基因多态和参与这一途径的辅因子(如叶酸、维生素B)的供应已被证明影响癌症风险甚至生存。在这篇综述中，我们从遗传学和生活方式两个方面总结了单碳代谢与乳腺癌风险相关的流行病学证据。我们还讨论了这一途径与乳腺癌存活率的关系以及化疗中单碳多态的调节。关于单碳代谢调节DNA甲基化的新证据表明，表观基因组的破坏可能是潜在的机制。预计会有更多的结果，并将转化为对普通民众预防疾病以及临床医生治疗和管理疾病的指导。
One-carbon metabolism is a network of biological reactions that plays critical role in DNA methylation and DNA synthesis, and in turn, facilitates the cross-talk between genetic and epigenetic processes. Genetic polymorphisms and supplies of cofactors (e.g. folate, vitamins B) involved in this pathway have been shown to influence cancer risk and even survival. In this review, we summarized the epidemiological evidence for one-carbon metabolism, from both genetics and lifestyle aspects, in relation to breast cancer risk. We also discussed this pathway in relation to breast cancer survival and the modulation of one-carbon polymorphism in chemotherapy. Emerging evidence on modulation of DNA methylation by one-carbon metabolism suggests that disruption of epigenome might have been the underlying mechanism. More results are expected and will be translated to guidance to the general population for disease prevention as well as to clinicians for treatment and management of the disease.