Continuous plug flow extraction of L-tryptophan using ionic liquid-based aqueous biphasic systems in small channels
Continuous plug flow extraction of L-tryptophan using ionic liquid-based aqueous biphasic systems in small channels
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DOI：
10.1016/j.seppur.2023.125468
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发表时间：
2023-10
影响因子：
8.6
通讯作者：
Yiota-Victoria Phakoukaki;Paul O'Shaughnessy;P. Angeli
中科院分区：
文献类型：
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作者：
Yiota-Victoria Phakoukaki;Paul O'Shaughnessy;P. Angeli
采用两种策略实现了常规溶剂萃取的双重过程强化。首先，通过利用连续的小通道，其次通过用新型离子液体基水性两相体系（IL-ABS）代替有机溶剂。在内径为0.5和0.8 mm的小通道和三种不同的IL-ABS中研究了氨基酸L-色氨酸的流动萃取。对于IL-ABS组合物18、20和22wt%K3PO4和C4 mimCl，测量两种不同L-色氨酸浓度（0.325和0.5wt%）的分配系数。增加常规盐和离子液体的重量组成增加了氨基酸对于顶部离子液体富集相的分配。连续萃取在活塞流状态下进行。提出了塞长度和膜厚度与毛细数的函数关系。发现在0.5mm通道中，使用20wt%ABS的萃取效率在15 s内达到95%，并且在0.8mm通道中在约40 s内达到95%。当比较IL-ABS时，22重量%在14秒内达到96%的提取效率，相比之下，20重量%在0.8 mm通道中的提取效率为70秒。对于所有研究的情况，总传质系数在0.05和0.2 s-1之间变化，这显著高于传统溶剂萃取系统。
A double process intensification of the conventional solvent extraction was accomplished by employing two strategies. Firstly, by utilizing continuous small channels and secondly by replacing organic solvents with novel ionic liquid based aqueous biphasic systems (IL-ABS). The flow extraction of the amino acid L-tryptophan was investigated in small channels with internal diameters of 0.5 and 0.8 mm and three different IL-ABS. The partition coefficients for two different L-tryptophan concentrations (0.325 and 0.5 wt%) were measured for IL-ABS compositions 18, 20 and 22 wt%K3PO4andC4mimCl. Increasing the weight composition of the conventional salt and the ionic liquid increased the partition of the amino acid for the top ionic liquid rich phase. The continuous extractions were carried out in the plug flow regime. Correlations were proposed for the plug length and the film thickness as functions of the capillary number. It was found that the extraction efficiency with the 20 wt% ABS reached 95 % in under 15 s in the 0.5 mm channel and in about 40 s in the 0.8 mm channel. When comparing the IL-ABS, the 22 wt% reached 96 % extraction efficiency in 14 s compared to the 70 s of the 20 wt% in the 0.8 mm channel. The overall mass transfer coefficients varied between 0.05 and 0.2 s−1for all cases studied, which were significantly higher than those in conventional solvent extraction systems.