Continuation of neurogenesis in the hippocampus of the adult macaque monkey
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
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DOI：
10.1073/pnas.96.10.5768
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发表时间：
1999-05-11
影响因子：
11.1
通讯作者：
Rakic, P
中科院分区：
文献类型：
--
作者：
Kornack, DR;Rakic, P
我们目前的证据表明，连续一代的神经元，少突胶质细胞和星形胶质细胞在成年猕猴的海马齿状回，使用免疫组化双标记溴脱氧尿苷和细胞类型特异性标记。我们估计，神经发生的相对速率约为10倍，低于成年啮齿动物齿状回的报告。然而，这三种类型的细胞在一个谨慎的大脑区域的产生表明，多能神经干细胞可能保留在成年灵长类动物海马体。这种演示的成年神经发生在非人类的旧世界灵长类动物，其系统发育接近人类，寿命长，和复杂的认知能力，建立猕猴作为一个无与伦比的动物模型，实验研究问题的神经发生在人类和提供新的见解，其意义在成年人的大脑。
We present evidence for continuous generation of neurons, oligodendrocytes, and astrocytes in the hippocampal dentate gyrus of adult macaque monkeys, using immunohistochemical double labeling for bromodeoxyuridine and cell-type-specific markers. We estimate that the relative rate of neurogenesis is approximately 10 times less than that reported in the adult rodent dentate gyrus. Nevertheless, the generation of these three cell types in a discreet brain region suggests that a multipotent neural stem cell may be retained in the adult primate hippocampus. This demonstration of adult neurogenesis in nonhuman Old World primates-with their phylogenetic proximity to humans, long Life spans, and elaborate cognitive abilities-establishes the macaque as an unexcelled animal model to experimentally investigate issues of neurogenesis in humans and offers new insights into its significance in the adult brain.