Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments
Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments
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DOI：
10.7554/elife.19295
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发表时间：
2016-11-18
期刊：
影响因子：
7.7
通讯作者：
Englitz, Bernhard
中科院分区：
文献类型：
--
作者：
Keine, Christian;Ruebsamen, Rudolf;Englitz, Bernhard
抑制在神经信号处理、成形和限制反应中起着至关重要的作用。在听觉系统中，抑制已经调节耳蜗核中的二级神经元，例如球形丛状细胞（SBC）。虽然抑制和兴奋的生理基础被很好地描述，但它们在信号处理中的功能相互作用仍然难以捉摸。使用的组合在体内松散的补丁记录，离子电渗药物的应用，并在蒙古沙鼠详细的信号分析，我们证明，抑制广泛共调谐与激励，并导致只有轻微的锐化的光谱响应特性。基于spectrotemporal感受野的复杂刺激和神经元输入-输出分析的组合揭示了抑制，使神经元输出在时间上比输入更稀疏，更可重复。总的来说，抑制在改善宽范围的输入强度的SBC的时间响应保真度中起着核心作用，从而为高保真信号处理提供了基础。
Inhibition plays a crucial role in neural signal processing, shaping and limiting responses. In the auditory system, inhibition already modulates second order neurons in the cochlear nucleus, e.g. spherical bushy cells (SBCs). While the physiological basis of inhibition and excitation is well described, their functional interaction in signal processing remains elusive. Using a combination of in vivo loose-patch recordings, iontophoretic drug application, and detailed signal analysis in the Mongolian Gerbil, we demonstrate that inhibition is widely co-tuned with excitation, and leads only to minor sharpening of the spectral response properties. Combinations of complex stimuli and neuronal input-output analysis based on spectrotemporal receptive fields revealed inhibition to render the neuronal output temporally sparser and more reproducible than the input. Overall, inhibition plays a central role in improving the temporal response fidelity of SBCs across a wide range of input intensities and thereby provides the basis for high-fidelity signal processing.