Extraneuronal binding of catecholamines and 3,4-dihydroxyphenylalanine (dopa) in salivary glands.
Extraneuronal binding of catecholamines and 3,4-dihydroxyphenylalanine (dopa) in salivary glands.
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唾液腺中儿茶酚胺和 3,4-二羟基苯丙氨酸（多巴）的神经元外结合。
DOI：
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发表时间：
1967
期刊：
影响因子：
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通讯作者：
Lars Olson
中科院分区：
文献类型：
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作者：
B. Hamberger;Karl‐Axel Norberg;Lars Olson
用Falck和Hillarp组织化学荧光技术，对经儿茶酚胺或多巴染毒或腺体切片与相同药物孵育的大鼠颌下腺和舌下腺进行了体内和体外研究。在实验条件下，儿茶酚胺和L-多巴很可能也被发现神经外结合在唾液腺实质中。本实验很可能显示了与生化技术所发现的相同类型的神经元外结合。看来，薄壁组织的某种活动是发生结合所必需的。除了在生化测量评估中的一个误差源，神经元外结合可能与递质机制有关。
In vivo and in vitro studies using the histochemical fluorescence technique of Falck and Hillarp were made on the submaxillary and sublingual glands of the rat after the administration of catecholamines or dopa, or the incubation of slices of the glands with the same drugs. Catecholamines and in all probability also L-dopa were found to be bound extraneuronally in the salivary gland parenchyma under the conditions of the experiments. It is probable that the present experiments visualize the same type of extraneuronal binding as has been found with biochemical techniques. It appears that a certain activity of the parenchyma is necessary for the binding to occur. Apart from being a source of error in the evaluation of biochemical measurements, extraneuronal binding may be of importance related to transmitter mechanisms.