Attenuation of widespread hypersensitivity to noxious mechanical stimuli by inhibition of GABAergic neurons of the right amygdala in a rat model of chronic back pain
Attenuation of widespread hypersensitivity to noxious mechanical stimuli by inhibition of GABAergic neurons of the right amygdala in a rat model of chronic back pain
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DOI：
10.1002/ejp.1921
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发表时间：
2022-02
影响因子：
3.6
通讯作者：
Ryota Tokunaga;Yukari Takahashi;Sara Touj;H. Hotta;H. Leblond;F. Kato;M. Piché
中科院分区：
文献类型：
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作者：
Ryota Tokunaga;Yukari Takahashi;Sara Touj;H. Hotta;H. Leblond;F. Kato;M. Piché
慢性原发性腰痛可能与未损伤组织的痛觉过敏和疼痛抑制降低有关。先前的研究表明，杏仁核参与疼痛调节和慢性疼痛，杏仁核中的神经元活动在持续性疼痛模型中改变，并且右侧杏仁核的中央核在对有害刺激的广泛超敏反应中起着积极的作用。
Chronic primary low back pain may be associated with hyperalgesia in uninjured tissues and with decreased pain inhibition. Previous studies have shown that the amygdala is involved in pain regulation and chronic pain, that neuronal activity in the amygdala is altered in models of persistent pain, and that the central nucleus of the right amygdala plays an active role in widespread hypersensitivity to noxious stimuli.