Effects of swimming on functional recovery after incomplete spinal cord injury in rats
Effects of swimming on functional recovery after incomplete spinal cord injury in rats
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DOI：
10.1089/neu.2006.23.908
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发表时间：
2006-06-01
影响因子：
4.2
通讯作者：
Magnuson, David S. K.
中科院分区：
文献类型：
--
作者：
Smith, Rebecca R.;Shum-Siu, Alice;Magnuson, David S. K.
负重跑台训练是脊髓损伤最有前途的康复策略之一。该策略旨在重新训练受伤水平以下的脊髓，以产生有意义的运动模式。然而，可以完成的步循环的数量受到损伤后神经肌肉系统的不良承重能力的限制。我们已经开始研究游泳作为一种康复策略，允许在标准大鼠模型的挫伤性脊髓损伤的高步数和高步周期频率。本研究的目的是评估游泳作为一种康复策略在大鼠挫伤在T9的效果。我们使用了游泳策略，有或没有皮肤反馈的基础上，在小鸡的原始工作由缪尔和同事。成年雌性大鼠（n = 27）在T9时接受中度至重度挫伤。使用旷场运动量表（BBB; Basso等人，1995年）和一种新的游泳评估，路易斯维尔游泳量表（LSS）。与未经训练的动物相比，接受有或没有皮肤反馈的游泳训练的大鼠在游泳过程中后肢功能有显着改善。接受游泳训练而没有皮肤反馈的大鼠比接受皮肤反馈训练的大鼠表现出更少的改善。非游泳组的大鼠在研究过程中表现出很少的改善。三组在地上行走方面表现出预期的改善，并且具有相似的终末BBB评分。这些发现表明，动物重新获得游泳的能力，只有经过训练，皮肤反馈改善了再训练过程。此外，这些数据表明，在T9的中度-重度挫伤后，地面行走的正常恢复过程是再训练过程的结果。
One of the most promising rehabilitation strategies for spinal cord injury is weight-supported treadmill training. This strategy seeks to re-train the spinal cord below the level of injury to generate a meaningful pattern of movement. However, the number of step cycles that can be accomplished is limited by the poor weight-bearing capability of the neuromuscular system after injury. We have begun to study swimming as a rehabilitation strategy that allows for high numbers of steps and a high step-cycle frequency in a standard rat model of contusive spinal cord injury. The purpose of the present study was to evaluate the effect of swimming as a rehabilitation strategy in rats with contusion injuries at T9. We used a swimming strategy with or without cutaneous feedback based on original work in the chick by Muir and colleagues. Adult female rats (n = 27) received moderately-severe contusion injuries at T9. Walking and swimming performance were evaluated using the Open-Field Locomotor Scale (BBB; Basso et al., 1995) and a novel swimming assessment, the Louisville Swimming Scale (LSS). Rats that underwent swim-training with or without cutaneous feedback showed a significant improvement in hindlimb function during swimming compared to untrained animals. Rats that underwent swim-training without cutaneous feedback showed less improvement than those trained with cutaneous feedback. Rats in the non-swimming group demonstrated little improvement over the course of the study. An three groups showed the expected improvement in over-ground walking and had similar terminal BBB scores. These findings suggest that animals re-acquire the ability to swim only if trained and that cutaneous feedback improves the re-training process. Further, these data suggest that the normal course of recovery of over-ground walking following moderately-severe contusion injuries at T9 is the result of a re-training process.