Investigation of systemic lupus erythematosus in Nogales, Arizona
Investigation of systemic lupus erythematosus in Nogales, Arizona
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DOI：
10.1093/aje/154.11.1029
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发表时间：
2001-12-01
影响因子：
5
通讯作者：
Kieszak, S
中科院分区：
文献类型：
--
作者：
Balluz, L;Philen, R;Kieszak, S
1996 年，亚利桑那州诺加利斯的一个公民团体向亚利桑那州卫生部报告，他们担心由于该地区暴露于环境污染，系统性红斑狼疮 (SLE) 的患病率可能过高。作者进行了一项两阶段研究，其中第一阶段的目标是识别潜在的系统性红斑狼疮病例并确定系统性红斑狼疮的患病率，第二阶段的目标是识别与系统性红斑狼疮发生相关的潜在风险因素，并评估系统性红斑狼疮与环境中农药和无机化合物暴露之间可能存在的关联。参与者包括 20 名确诊病例和 36 名对照者。作者发现 SLE 的患病率为每 100,000 人中有 103 例（95% 置信区间：56, 149），比美国人口的患病率高出两到七倍。他们在病例和对照中检测到 1,1-二氯-2,2-双-(对氯苯基)乙烯和有机磷酸酯代谢物水平升高。两者的水平均高于美国人口的参考平均值。作者发现农药水平升高与疾病状况之间没有统计关联。他们的结果表明，诺加利斯的系统性红斑狼疮患病率高于美国人口中报告的患病率，并且病例和对照都曾接触过氯化农药，并且持续接触过有机磷酸酯。
In 1996, a citizens group in Nogales, Arizona, reported to the Arizona Department of Health their concerns about a possible excess prevalence of systemic lupus erythematosus (SLE) due to exposure to environmental contamination in the area. The authors conducted a two-phase study in which the objectives of phase I were to identify potential SLE cases and to determine the prevalence of SLE and the objectives of phase II were to identify potential risk factors associated with the development of SLE and to evaluate the possible association between SLE and environmental exposure to pesticides and inorganic compounds. Participants included 20 confirmed cases and 36 controls. The authors found the prevalence of SLE to be 103 cases per 100,000 population (95 percent confidence interval: 56, 149), two to seven times higher than the prevalence in the US population. They detected elevated levels of 1,1-dichloro-2,2-bis-(p-chorophenyl)ethylene and organophosphate metabolites among cases and controls. In both, levels were higher than the reference mean for the US population. The authors found no statistical association between elevated levels of pesticides and disease status. Their results show that the prevalence of SLE in Nogales is higher than the reported prevalence in the US population and that both cases and controls had past exposure to chlorinated pesticides and have ongoing exposure to organophosphates.