F-Fluorodeoxyglucose Positron Emission Tomography and the Prognosis of Patients with Pancreatic Adenocarcinoma
F-Fluorodeoxyglucose Positron Emission Tomography and the Prognosis of Patients with Pancreatic Adenocarcinoma
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F-氟脱氧葡萄糖正电子发射断层扫描与胰腺腺癌患者的预后
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发表时间：
1997
期刊：
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通讯作者：
H. Ochi
中科院分区：
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作者：
Y. Sakurai;H. Ochi
背景通过正电子发射断层扫描检测氟脱氧葡萄糖（FDG）Bunzo Nakata，M.D. phy（PET）可用于测量肿瘤细胞的糖酵解活性。虽然Yong-Suk Chung，医学博士胰腺癌患者的预后通常很差，ShigehikoNishimura，M.D.的患者有良好的关节炎，可以通过确定的程度Tamahiro西原，医学博士。FDG整合到肿瘤中。Yasuhiro Sakurai，医学博士方法. 14例经组织学证实的胰腺腺癌患者。坏疽性口炎行F-FDG PET检查。F-FDG的标准化摄取值（SUV）Terue Okamura，M.D.根据患者的年龄将患者分为高SUV（≤ 3.0）和低SUV（≤ 3.0）两组。组Hironobu Ochi，医学博士结果这两组在年龄、肿瘤Michio Sowa，M.D.，飞行控制系统位置和大小分期和治疗然而，Kaplan-Meier法分析显示，各组有不同的风险（对数秩检验，P <0.05）。1大坂市立大学第一外科高SUV患者的平均生存期为5个月，而日本大坂大学医学院的患者的平均生存期为5个月。低SUV的患者的平均寿命为14个月。大坂市核医学2部UniSUV与肿瘤大小（0.56）、血清碳水化合物抗原19 - 9（0.39）或日本大坂癌症大学医学院之间无强相关性。胚抗原（0.52）。结论. F-FDG计算的SUV可作为胰腺癌患者的预后指标。癌症1997; 79：695 - 9.
BACKGROUND. Fluorodeoxyglucose (FDG) detected by positron emission tomograBunzo Nakata, M.D. phy (PET) can be used to measure the glycolytic activity of tumor cells. Though Yong-Suk Chung, M.D. the prognosis of patients with pancreatic adenocarcinoma is usually poor, a subset Shigehiko Nishimura, M.D. of patients with good prognoses may be discovered by determining the degree of Tamahiro Nishihara, M.D. FDG integration into tumors. Yasuhiro Sakurai, M.D. METHODS. Fourteen patients with histologically proven pancreatic adenocarciTetsuji Sawada, M.D. noma underwent F-FDG PET. The standardized uptake value (SUV) of F-FDG Terue Okamura, M.D. was calculated, and the patients were divided into high (¢3.0) and low (õ3.0) SUV Joji Kawabe, M.D. groups. Hironobu Ochi, M.D. RESULTS. The two groups were not significantly different in terms of age, tumor Michio Sowa, M.D., F.A.C.S. location and size, staging, and treatment. However, analysis by the Kaplan-Meier method revealed that the groups had different prognoses (log rank test, P õ 0.05). 1 First Department of Surgery, Osaka City UniThe mean survival of patients with high SUV was 5 months, whereas that of patients versity Medical School, Osaka, Japan. with low SUV was 14 months. There were not strong correlations between the 2 Division of Nuclear Medicine, Osaka City UniSUVs and tumor size (0.56), serum carbohydrate antigen 19-9 (0.39), or carcinoemversity Medical School, Osaka, Japan. bryonic antigen (0.52). CONCLUSIONS. SUV calculated with F-FDG can be utilized as a prognostic factor for patients with pancreatic adenocarcinoma. Cancer 1997; 79:695–9.