Isolated teratozoospermia does not affect in vitro fertilization outcome and is not an indication for intracytoplasmic sperm injection
Isolated teratozoospermia does not affect in vitro fertilization outcome and is not an indication for intracytoplasmic sperm injection
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DOI：
10.1016/j.fertnstert.2007.01.057
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发表时间：
2007-12-01
影响因子：
6.7
通讯作者：
Grifo, Jamie
中科院分区：
文献类型：
--
作者：
Keegan, Brian Robert;Barton, Sara;Grifo, Jamie
目的：重新评估开始IVF的夫妇中孤立畸形精子症的临床治疗。设计：回顾性分析535个周期的生育指数。设置：一个大型的大学生育中心。患者：在2002年接受第一个和/或第二个IVF周期前12个月内在我们中心使用Kruger/Tyberberg严格标准进行精液分析的连续夫妇（n = 495）-2004年，在取卵当天有> 200万个洗后活动精子。干预：卵子通过常规IVF或ICSI受精。所有病例的精液分析和配子/胚胎操作均标准化。主要结果测量：受精率、受精失败率、妊娠率和活产率。结果：与单独畸形精子症夫妇相比，第一和第二IVF周期的受精率、受精失败率、妊娠率和活产率无统计学差异（
Objective: To reevaluate clinical management of isolated teratozoospermia, in couples initiating IVF.Design: Retrospective analysis of fertility indices in 535 cycles.Setting: A large, university-based fertility center.Patient(s): Consecutive couples (n = 495) who had a semen analysis using Kruger/Tyberberg strict criteria at our center within 12 months before undergoing their first and/or second IVF cycle in 2002-2004 with >2 million postwash, motile sperm on the day of egg retrieval.Intervention(s): Eggs were fertilized either by conventional IVF or ICSI. Semen analysis and gamete/embryo manipulation was standardized in all cases.Main Outcome Measure(s): Fertilization, fertilization failure, pregnancy, and live birth rates.Result(s): There was no statistical difference in fertilization, fertilization failure, pregnancy, and live birthrates in the first or second IVF cycle when comparing couples with isolated teratozoospermia (