Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys
Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys
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DOI：
10.1152/ajpregu.00535.2004
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发表时间：
2005-02-01
影响因子：
2.8
通讯作者：
Ladenheim, EE
中科院分区：
文献类型：
--
作者：
Moran, TH;Smedh, U;Ladenheim, EE
多肽YY3-36[PYY(3-36)]是一种胃肠道多肽，在进食后被释放到循环中，最近被认为在控制食物摄入量方面发挥作用。据报道，PYY(3-36)在啮齿动物和人类受试者外周给药后抑制食物摄取。为了更全面地描述PYY(3-36)的潜在摄食作用，我们研究了不同剂量范围的PYY(3-36)(0.3-3.0nmol/kg)对雄性恒河猴液体胃排空和每日6小时摄食量的影响。肌肉注射PYY(3-36)对生理盐水胃排空有剂量依赖性抑制作用，在3nmol/kg剂量时抑制作用最强。在每日进食6小时前肌肉注射PYY(3-36)，在剂量为1和3nmol/kg时，显著减少摄食量。对食物获取的6小时内食物摄入模式的分析表明，PYY(3-36)增加了第一餐的潜伏期，并在不改变进餐数量的情况下减少了平均进餐大小。虽然单剂量的PYY(3-36)减少了摄入量，但在连续几天的多次给药中，对食物摄入量的抑制作用并不持续。总之，这些数据表明，PYY(3-36)有能力减少非人类灵长类动物在急性测试情况下的食物摄入量。这是否是内源性多肽的生理作用还有待确定。
Peptide YY3-36 [PYY(3-36)], a gastrointestinal peptide that is released into the circulation in response to ingesting a meal, has recently been suggested to play a role in controlling food intake. PYY(3-36) has been reported to inhibit food intake following peripheral administration in rodents and in human subjects. To more fully characterize the potential feeding actions of PYY(3-36), we examined the ability of a dose range of PYY(3-36) (0.3-3.0 nmol/kg) to affect liquid gastric emptying and daily 6-h food intake in male rhesus monkeys. Intramuscular PYY(3-36) produced a dose-related inhibition of saline gastric emptying that was maximal at a dose of 3 nmol/kg. Intramuscular PYY(3-36) administered before daily 6-h food access produced significant feeding reductions at doses of 1 and 3 nmol/kg. Analyses of the patterns of food intake across the 6-h period of food access revealed that PYY(3-36) increased the latency to the first meal and reduced average meal size without altering meal number. Although single doses of PYY(3-36) reduced intake, a suppressive effect on food intake was not sustained over multiple administrations across successive days. Together, these data suggest that PYY(3-36) has the ability to reduce food intake in acute test situations in nonhuman primates. Whether this is a physiological action of the endogenous peptide remains to be determined.